Y019_THEMA
ID Y019_THEMA Reviewed; 256 AA.
AC Q56318;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Uncharacterized oxidoreductase TM_0019;
DE EC=1.-.-.-;
GN OrderedLocusNames=TM_0019;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=8550425; DOI=10.1128/jb.178.1.248-257.1996;
RA Kletzin A., Adams M.W.W.;
RT "Molecular and phylogenetic characterization of pyruvate and 2-
RT ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and
RT pyruvate ferredoxin oxidoreductase from Thermotoga maritima.";
RL J. Bacteriol. 178:248-257(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; X85171; CAA59459.1; -; Genomic_DNA.
DR EMBL; AE000512; AAD35113.1; -; Genomic_DNA.
DR PIR; E72427; E72427.
DR RefSeq; NP_227835.1; NC_000853.1.
DR RefSeq; WP_004082464.1; NZ_CP011107.1.
DR AlphaFoldDB; Q56318; -.
DR SMR; Q56318; -.
DR STRING; 243274.THEMA_04705; -.
DR EnsemblBacteria; AAD35113; AAD35113; TM_0019.
DR KEGG; tma:TM0019; -.
DR eggNOG; COG1028; Bacteria.
DR InParanoid; Q56318; -.
DR OMA; WEVANVI; -.
DR OrthoDB; 1356861at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..256
FT /note="Uncharacterized oxidoreductase TM_0019"
FT /id="PRO_0000054866"
FT ACT_SITE 153
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 9..33
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 140
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 130..136
FT /note="RGGGVII -> TRWRSDH (in Ref. 1; CAA59459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 256 AA; 28078 MW; D68160B1D7980C6B CRC64;
MLEGKVAVVT GGGQGIGAAI AQLFAENGMK VVIAEIDEEA GVEREEMLRE RGLDVTFVKT
DVADENSVKN MVRKTVEIYG GVDVLVNNAA VMSVKSIFER PLEEWERVIR VNLTGPYICS
RYCAEEMIKR GGGVIINIAS TRAFQSEPDT EPYSASKGGL VALTHSLAVS LSRYHIRVVS
ISPGWIETSE WKKKSLRKKP DLRPIDHEQH PAGRVGNPLD IAHLCVFLAD DEKAGFITGT
NFIVDGGMTV KMIYEE
