CAPPA_PICTO
ID CAPPA_PICTO Reviewed; 508 AA.
AC Q6L0F3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_01904};
DE Short=PEPC {ECO:0000255|HAMAP-Rule:MF_01904};
DE Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_01904};
DE EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01904};
GN Name=ppcA {ECO:0000255|HAMAP-Rule:MF_01904}; OrderedLocusNames=PTO0964;
OS Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS 100828).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Picrophilaceae; Picrophilus.
OX NCBI_TaxID=263820;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
RX PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA Schepers B., Dock C., Antranikian G., Liebl W.;
RT "Genome sequence of Picrophilus torridus and its implications for life
RT around pH 0.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
CC -!- FUNCTION: Catalyzes the irreversible beta-carboxylation of
CC phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon
CC dicarboxylic acid source for the tricarboxylic acid cycle.
CC {ECO:0000255|HAMAP-Rule:MF_01904}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01904}.
CC -!- SIMILARITY: Belongs to the PEPCase type 2 family. {ECO:0000255|HAMAP-
CC Rule:MF_01904}.
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DR EMBL; AE017261; AAT43549.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6L0F3; -.
DR SMR; Q6L0F3; -.
DR STRING; 263820.PTO0964; -.
DR EnsemblBacteria; AAT43549; AAT43549; PTO0964.
DR KEGG; pto:PTO0964; -.
DR PATRIC; fig|263820.9.peg.1003; -.
DR eggNOG; arCOG04435; Archaea.
DR HOGENOM; CLU_517433_0_0_2; -.
DR OMA; QSAFRYD; -.
DR Proteomes; UP000000438; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR HAMAP; MF_01904; PEPcase_type2; 1.
DR InterPro; IPR007566; PEP_COase_arc-type.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR Pfam; PF14010; PEPcase_2; 1.
DR PIRSF; PIRSF006677; UCP006677; 1.
DR SUPFAM; SSF51621; SSF51621; 1.
DR TIGRFAMs; TIGR02751; PEPCase_arch; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation; Lyase; Magnesium; Reference proteome.
FT CHAIN 1..508
FT /note="Phosphoenolpyruvate carboxylase"
FT /id="PRO_0000309606"
SQ SEQUENCE 508 AA; 58714 MW; 2EE5AB862B179318 CRC64;
MAIAMIPKTM STQHPDNAKM PAWASEKSMI RNDDEVEEAY QCYTIGIKEV MWDAEGKDVD
THVLRKLISK NHEFFEKNVL GSDIFLTYRV PNPAIEGTER KVLTETLESI PVNYDVFNTV
YKRDIPPIFE VILPFTTSSK DLLNIAKYYE KAVAARDEIE LYDNVMVKNI LGETKPKKIN
IIPLIEDKDS MFNIDGIVKN FARAVSAKKM RVFIARSDPA MNYGMIPAVL MSKYAASRLC
KMNDDIENYP IVGVGSSTFR GRFSPENIEK SLYEYSNYYT FTLQSAFKYD YPQDSVKNSI
NIINRHERSF DYLEDYEEEI IKNAVNKYVI NYQKIIEKLA PAINNITMYL PKRRSRKLHI
GLFGYSRSTG NVTLPRAISF VGAMYSMGLP PEIIGISSLL NMKDDELDII EKTYINLRSD
IMESSSYLNY EVFDALKDVY KIDQETINMI KADVKYIENN YGIKSDLGYE RERHNYLSSL
MNLAFKNHDF ENTRKYILDM ALIRKFIG
