ID   Y023_MYCTU              Reviewed;         256 AA.
AC   P9WMI3; L0T2B8; P67704; P71593;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv0023;
GN   OrderedLocusNames=Rv0023; ORFNames=MTCY10H4.23;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION IN HUMAN MACROPHAGES.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16483748; DOI=10.1016/j.resmic.2005.10.007;
RA   Cappelli G., Volpe E., Grassi M., Liseo B., Colizzi V., Mariani F.;
RT   "Profiling of Mycobacterium tuberculosis gene expression during human
RT   macrophage infection: upregulation of the alternative sigma factor G, a
RT   group of transcriptional regulators, and proteins with unknown function.";
RL   Res. Microbiol. 157:445-455(2006).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: Up-regulated 12-fold 7 days after infection of human
CC       macrophages. {ECO:0000269|PubMed:16483748}.
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DR   EMBL; AL123456; CCP42745.1; -; Genomic_DNA.
DR   PIR; E70700; E70700.
DR   RefSeq; NP_214537.1; NC_000962.3.
DR   RefSeq; WP_003400391.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WMI3; -.
DR   STRING; 83332.Rv0023; -.
DR   PaxDb; P9WMI3; -.
DR   DNASU; 887062; -.
DR   GeneID; 887062; -.
DR   KEGG; mtu:Rv0023; -.
DR   TubercuList; Rv0023; -.
DR   eggNOG; COG1396; Bacteria.
DR   OMA; KPHKGTV; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..256
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv0023"
FT                   /id="PRO_0000149772"
FT   DOMAIN          10..64
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   256 AA;  27188 MW;  28123C7DF9036DAC CRC64;
     MSRESAGAAI RALRESRDWS LADLAAATGV STMGLSYLER GARKPHKSTV QKVENGLGLP
     PGTYSRLLVA ADPDAELARL IAAQPSNPTA VRRAGAVVVD RHSDTDVLEG YAEAQLDAIK
     SVIDRLPATT SNEYETYILS VIAQCVKAEM LAASSWRVAV NAGADSTGRL MEHLRALEAT
     RGALLERMPT SLSARFDRAC AQSSLPEAVV AALIGVGADE MWDIRNRGVI PAGALPRVRA
     FVDAIEASHD ADEGQQ