CAPPA_PYRAR
ID CAPPA_PYRAR Reviewed; 460 AA.
AC A4WJM7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_01904};
DE Short=PEPC {ECO:0000255|HAMAP-Rule:MF_01904};
DE Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_01904};
DE EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01904};
GN Name=ppcA {ECO:0000255|HAMAP-Rule:MF_01904}; OrderedLocusNames=Pars_1014;
OS Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=340102;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700994 / DSM 13514 / JCM 11321 / PZ6;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Cozen A.E.,
RA Fitz-Gibbon S.T., House C.H., Saltikov C., Lowe T.M., Richardson P.;
RT "Complete sequence of Pyrobaculum arsenaticum DSM 13514.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the irreversible beta-carboxylation of
CC phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon
CC dicarboxylic acid source for the tricarboxylic acid cycle.
CC {ECO:0000255|HAMAP-Rule:MF_01904}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01904}.
CC -!- SIMILARITY: Belongs to the PEPCase type 2 family. {ECO:0000255|HAMAP-
CC Rule:MF_01904}.
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DR EMBL; CP000660; ABP50594.1; -; Genomic_DNA.
DR AlphaFoldDB; A4WJM7; -.
DR SMR; A4WJM7; -.
DR STRING; 340102.Pars_1014; -.
DR EnsemblBacteria; ABP50594; ABP50594; Pars_1014.
DR KEGG; pas:Pars_1014; -.
DR HOGENOM; CLU_517433_0_0_2; -.
DR OMA; QSAFRYD; -.
DR PhylomeDB; A4WJM7; -.
DR Proteomes; UP000001567; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR HAMAP; MF_01904; PEPcase_type2; 1.
DR InterPro; IPR007566; PEP_COase_arc-type.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR Pfam; PF14010; PEPcase_2; 1.
DR PIRSF; PIRSF006677; UCP006677; 1.
DR SUPFAM; SSF51621; SSF51621; 1.
DR TIGRFAMs; TIGR02751; PEPCase_arch; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation; Lyase; Magnesium.
FT CHAIN 1..460
FT /note="Phosphoenolpyruvate carboxylase"
FT /id="PRO_0000309608"
SQ SEQUENCE 460 AA; 51926 MW; BC72C5AC78BD73DC CRC64;
MMHIPRLMCT QHPDTTVKIT TAEEVDEAIV AYTAYGCDEV MVDYEGKMTP YGQPKEIVMK
AIRGDVPLGD EFYITVRLPN PKLEEFDRAM LSLEAALVAN YFSRRYADAQ AVRWVVLPMV
EDFDTVILVR RMLRRKAEIY KSETGVDVGE VEVIPLIEDA FVQVKAKVIV GEVFKSEEAR
EVRVFLGKSD SAVRHGHLAS ALAIIYAMSK LKEFEAESGI RVRPILGMGS PPFRGALNNP
RLAHLEVVQY AGYYTATIQS AVRYDTSLDE YVKVRESILN ACCGTRGLVG EEVLPLIQEA
SAKYRSQAMK HVDKIAEVAR LVPSTRDRVS WKEYGRSLLD GDRVVHMPRA IVYTSAWYAM
GFPPTLIDAP LLLELAKSDK LDAVFKLLPT YKMELEYDYE FFDPQTARNY LSEELVYAAV
ELADYLGVEA RPTPTYTALL KMPRSEPNII ALSKYRKFLG
