ID   Y033_METJA              Reviewed;         539 AA.
AC   Q60356;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Uncharacterized FAD-dependent oxidoreductase MJ0033;
GN   OrderedLocusNames=MJ0033;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
CC       FRD/SDH subfamily. {ECO:0000305}.
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DR   EMBL; L77117; AAB98014.1; -; Genomic_DNA.
DR   PIR; A64304; A64304.
DR   RefSeq; WP_010869524.1; NC_000909.1.
DR   AlphaFoldDB; Q60356; -.
DR   SMR; Q60356; -.
DR   STRING; 243232.MJ_0033; -.
DR   PRIDE; Q60356; -.
DR   EnsemblBacteria; AAB98014; AAB98014; MJ_0033.
DR   GeneID; 1450871; -.
DR   KEGG; mja:MJ_0033; -.
DR   eggNOG; arCOG00571; Archaea.
DR   HOGENOM; CLU_014312_8_1_2; -.
DR   InParanoid; Q60356; -.
DR   OMA; PTAHHFM; -.
DR   OrthoDB; 8547at2157; -.
DR   PhylomeDB; Q60356; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 1.
DR   Gene3D; 3.90.700.10; -; 1.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR   InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR   InterPro; IPR030664; SdhA/FrdA/AprA.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR11632; PTHR11632; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   SUPFAM; SSF46977; SSF46977; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   SUPFAM; SSF56425; SSF56425; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..539
FT                   /note="Uncharacterized FAD-dependent oxidoreductase MJ0033"
FT                   /id="PRO_0000158670"
FT   ACT_SITE        227
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        243
FT                   /evidence="ECO:0000250"
FT   BINDING         6..20
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  60398 MW;  89FF7AE3D6268795 CRC64;
     MKTDILIIGG GGAAARAAIE CRDKNVIIAV KGLFGKSGCT VMAEGGYNAV FNPKDSFKKH
     FYDTVKGGGF INNPKLVEIL VKNAPKELLN LERFGALFDR TEDGFIAQRP FGGQSFNRTC
     YCGDRTGHEI MRGLMEYISK FERIKILEEV MAIKLIVKDN RCYGAIFLDL KTGNIFPIFA
     KATILATGGA GQLYPITSNP IQKTGDGFAI AYNEGAELID MEMVQFHPTG MVGTGILVTE
     AVRGEGGILY NKYKERFMVR YDKERMELST RDVVARAIYK EIQEGRGVNG GVYLDVSHLP
     NEVIEKKLET MLKQFLRVGI DIRKEPMIVS PTAHHFMGGL KINERCETNI IGLFACGEVT
     GGVHGANRLG GNALADTQVF GAIAGKSAKE FVENHDFNNI DAEEDVAKIL EEINSLKGDL
     NVYNLIEDLR KVMWDYVSII RNEDGLKKAL EKIDEIERNI DNVKVNGIID LQNYFELKNM
     VVVAKLVTKS ALYRKESRGA HYREDFPETK EEWRGNIIIK GKKMWFEKLD YSVFQNFLE