Y037_MYCTO
ID Y037_MYCTO Reviewed; 441 AA.
AC P9WJY0; L0T278; P0A5C1; P71607;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 27.
DE RecName: Full=Uncharacterized MFS-type transporter MT0042;
GN OrderedLocusNames=MT0042;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK44265.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE000516; AAK44265.1; ALT_INIT; Genomic_DNA.
DR PIR; C70702; C70702.
DR AlphaFoldDB; P9WJY0; -.
DR EnsemblBacteria; AAK44265; AAK44265; MT0042.
DR KEGG; mtc:MT0042; -.
DR PATRIC; fig|83331.31.peg.42; -.
DR HOGENOM; CLU_052021_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..441
FT /note="Uncharacterized MFS-type transporter MT0042"
FT /id="PRO_0000427751"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 441 AA; 45793 MW; DDB0DDEA94BCAD99 CRC64;
MPRVEVGLVI HSRMHARAPV DVWRSVRSLP DFWRLLQVRV ASQFGDGLFQ AGLAGALLFN
PDRAADPMAI AGAFAVLFLP YSLLGPFAGA LMDRWDRRWV LVGANTGRLA LIAGVGTILA
VGAGDVPLLV GALVANGLAR FVASGLSAAL PHVVPREQVV TMNSVAIASG AVSAFLGANF
MLLPRWLLGS GDEGASAIVF LVAIPVSIAL LWSLRFGPRV LGPDDTERAI HGSAVYAVVT
GLLHGARTVV QLPTVAAGLS GLAAHRMVVG INSLLILLLV RHVTARAVGG LGTALLFFAA
TGLGAFLANV LTPTAIRRWG RYATANGALA AAATIQVAAA GLLVPVMVVC GFLLGVAGQV
VKLCADSAMQ MDVDDALRGH VFAVQDALFW VSYILSITVA AALIPEHGHA PVFVLFGSAI
YLAGLVVHTI VGRRGQPVIG R