ID   Y037_MYCTU              Reviewed;         441 AA.
AC   P9WJY1; L0T278; P0A5C1; P71607;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized MFS-type transporter Rv0037c;
GN   OrderedLocusNames=Rv0037c; ORFNames=MTCY10H4.37c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP42759.1; -; Genomic_DNA.
DR   PIR; C70702; C70702.
DR   RefSeq; NP_214551.1; NC_000962.3.
DR   RefSeq; WP_003400431.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WJY1; -.
DR   STRING; 83332.Rv0037c; -.
DR   PaxDb; P9WJY1; -.
DR   DNASU; 887042; -.
DR   GeneID; 887042; -.
DR   KEGG; mtu:Rv0037c; -.
DR   PATRIC; fig|83332.111.peg.42; -.
DR   TubercuList; Rv0037c; -.
DR   eggNOG; COG2814; Bacteria.
DR   OMA; MRFCYGA; -.
DR   PhylomeDB; P9WJY1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..441
FT                   /note="Uncharacterized MFS-type transporter Rv0037c"
FT                   /id="PRO_0000103654"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   441 AA;  45866 MW;  461B7AF72F1BB027 CRC64;
     MPRVEVGLVI HSRMHARAPV DVWRSVRSLP DFWRLLQVRV ASQFGDGLFQ AGLAGALLFN
     PDRAADPMAI AGAFAVLFLP YSLLGPFAGA LMDRWDRRWV LVGANTGRLA LIAGVGTILA
     VGAGDVPLLV GALVANGLAR FVASGLSAAL PHVVPREQVV TMNSVAIASG AVSAFLGANF
     MLLPRWLLGS GDEGASAIVF LVAIPVSIAL LWSLRFGPRV LGPDDTERAI HGSAVYAVVT
     GWLHGARTVV QLPTVAAGLS GLAAHRMVVG INSLLILLLV RHVTARAVGG LGTALLFFAA
     TGLGAFLANV LTPTAIRRWG RYATANGALA AAATIQVAAA GLLVPVMVVC GFLLGVAGQV
     VKLCADSAMQ MDVDDALRGH VFAVQDALFW VSYILSITVA AALIPEHGHA PVFVLFGSAI
     YLAGLVVHTI VGRRGQPVIG R