ID   Y038_MYCBO              Reviewed;         441 AA.
AC   P0A5C2; A0A1R3XWB8; P71607; X2BDU7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uncharacterized MFS-type transporter Mb0038c;
GN   OrderedLocusNames=BQ2027_MB0038C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Drug:H(+)
CC       antiporter-3 (DHA3) (TC 2.A.1.21) family. {ECO:0000305}.
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DR   EMBL; LT708304; SIT98398.1; -; Genomic_DNA.
DR   RefSeq; NP_853707.1; NC_002945.3.
DR   RefSeq; WP_003400431.1; NC_002945.4.
DR   AlphaFoldDB; P0A5C2; -.
DR   TCDB; 2.A.1.21.14; the major facilitator superfamily (mfs).
DR   EnsemblBacteria; SIT98398; SIT98398; BQ2027_MB0038C.
DR   PATRIC; fig|233413.5.peg.44; -.
DR   OMA; MRFCYGA; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..441
FT                   /note="Uncharacterized MFS-type transporter Mb0038c"
FT                   /id="PRO_0000103655"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   441 AA;  45866 MW;  461B7AF72F1BB027 CRC64;
     MPRVEVGLVI HSRMHARAPV DVWRSVRSLP DFWRLLQVRV ASQFGDGLFQ AGLAGALLFN
     PDRAADPMAI AGAFAVLFLP YSLLGPFAGA LMDRWDRRWV LVGANTGRLA LIAGVGTILA
     VGAGDVPLLV GALVANGLAR FVASGLSAAL PHVVPREQVV TMNSVAIASG AVSAFLGANF
     MLLPRWLLGS GDEGASAIVF LVAIPVSIAL LWSLRFGPRV LGPDDTERAI HGSAVYAVVT
     GWLHGARTVV QLPTVAAGLS GLAAHRMVVG INSLLILLLV RHVTARAVGG LGTALLFFAA
     TGLGAFLANV LTPTAIRRWG RYATANGALA AAATIQVAAA GLLVPVMVVC GFLLGVAGQV
     VKLCADSAMQ MDVDDALRGH VFAVQDALFW VSYILSITVA AALIPEHGHA PVFVLFGSAI
     YLAGLVVHTI VGRRGQPVIG R