ID   CAPP_AERS4              Reviewed;         877 AA.
AC   A4SIM0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_00595};
DE            Short=PEPC {ECO:0000255|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_00595};
GN   Name=ppc {ECO:0000255|HAMAP-Rule:MF_00595}; OrderedLocusNames=ASA_0576;
OS   Aeromonas salmonicida (strain A449).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=382245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A449;
RX   PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA   Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA   Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA   Brown L.L.;
RT   "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT   the evolution of a fish pathogen.";
RL   BMC Genomics 9:427-427(2008).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC       for the tricarboxylic acid cycle. {ECO:0000255|HAMAP-Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00595};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00595};
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00595}.
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DR   EMBL; CP000644; ABO88742.1; -; Genomic_DNA.
DR   RefSeq; WP_005313775.1; NC_009348.1.
DR   AlphaFoldDB; A4SIM0; -.
DR   SMR; A4SIM0; -.
DR   STRING; 382245.ASA_0576; -.
DR   EnsemblBacteria; ABO88742; ABO88742; ASA_0576.
DR   KEGG; asa:ASA_0576; -.
DR   eggNOG; COG2352; Bacteria.
DR   HOGENOM; CLU_006557_2_0_6; -.
DR   OMA; PWVFGWT; -.
DR   OrthoDB; 398146at2; -.
DR   Proteomes; UP000000225; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PTHR30523; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation; Lyase; Magnesium.
FT   CHAIN           1..877
FT                   /note="Phosphoenolpyruvate carboxylase"
FT                   /id="PRO_1000025545"
FT   ACT_SITE        138
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00595"
FT   ACT_SITE        543
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00595"
SQ   SEQUENCE   877 AA;  99049 MW;  F02D83589517C14B CRC64;
     MNEKYAALRA NVGMLGQLLG KSIKDHQGQA FLDKIETIRQ LAKSSRKGNE ADRERLLETL
     RTLSDDELLP VARAFSQFLN LANVAEQFHT ISRRCEEQVC TPDPLEQMFA KLKASNLSQE
     AIIQAVRELD IDLVLTAHPT EVTRRTLIHK HVQLNDCLEA LELSDLLPRE RDKILNRIEQ
     LVNQAWHTNE IREQRPTPVD EAKWGFAVVE NSLWPAIPEF MRNLDERLQQ HLGVRLPLDA
     APVKFTSWMG GDRDGNPFVT AKVTAEVLEL GRWMAVSLFY KDIKELTSEL SMSDCTDAVR
     ERVGDHPEPY RALVRELREA LRETQEYLTA KVQGQVSESR DLITTTAQLR EPLELCYHSM
     HACGMGNIAD GMLLDVLRKL ACFGIHLVKL DIRQDGERHG QVFSELTRYL GMGDYAEWSE
     DDKQAFLLNE LNSRRPLIPT DWEPSDETRE TIDTCRVIAQ HDPDAFGIYI ISMAGAPSDV
     LAVQLLLKEA GCKFRMPVAP LFETQEDLMA GTAVMERLLS VDWYRGYIQG RQYVMIGYSD
     SAKDAGMMAA GWAQYAAMES LVALAEASNL RLTLFHGRGG TVGRGGAPAH QAILSQPPGS
     LRGGLRVTEQ GEMIRFKFGL PKVAIHSLNL YTSAVLEGNL LPPPKPKESW RAVMEQLATV
     SCDHYRSIVR GHPDFVPYFR AATPEMELGK LPLGSRPAKR KPNGGVESLR AIPWIFAWTQ
     NRLMLPAWLG AHKGLEHAIT DGQKSVLEEM SRQWPFFRTR LEMLEMVFLK ADLWLAEYYD
     TRLVPQELWN LGKQLRQELA DAIQIVLQLR PQGDLLDDQP WIKESINLRN PYTDPLNVLQ
     VELLGRSRSH TETLHPELDQ ALMVTIAGIA AGMRNTG