Y0430_BRAHW
ID Y0430_BRAHW Reviewed; 346 AA.
AC C0QY54; C4MGF0;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Putative ABC transporter periplasmic binding protein BHWA1_00430;
DE AltName: Full=P-H7;
DE Flags: Precursor;
GN Name=ssuA; OrderedLocusNames=BHWA1_00430;
OS Brachyspira hyodysenteriae (strain ATCC 49526 / WA1).
OC Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira.
OX NCBI_TaxID=565034;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND BIOTECHNOLOGY.
RX PubMed=19179021; DOI=10.1016/j.vetmic.2008.12.018;
RA Song Y., La T., Phillips N.D., Bellgard M.I., Hampson D.J.;
RT "A reverse vaccinology approach to swine dysentery vaccine development.";
RL Vet. Microbiol. 137:111-119(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49526 / WA1;
RX PubMed=19262690; DOI=10.1371/journal.pone.0004641;
RA Bellgard M.I., Wanchanthuek P., La T., Ryan K., Moolhuijzen P.,
RA Albertyn Z., Shaban B., Motro Y., Dunn D.S., Schibeci D., Hunter A.,
RA Barrero R., Phillips N.D., Hampson D.J.;
RT "Genome sequence of the pathogenic intestinal spirochete Brachyspira
RT hyodysenteriae reveals adaptations to its lifestyle in the porcine large
RT intestine.";
RL PLoS ONE 4:E4641-E4641(2009).
CC -!- FUNCTION: Probably part of an ABC transporter complex.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- BIOTECHNOLOGY: Has shown promise in a 4-component vaccine with SecA (AC
CC C0QZS7), BHWA1_00569 (AC C0QYX7) and FlaAL (AC C0QWY9).
CC {ECO:0000269|PubMed:19179021}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein SsuA/TauA
CC family. {ECO:0000305}.
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DR EMBL; EU555154; ACD74824.1; -; Genomic_DNA.
DR EMBL; CP001357; ACN82926.1; -; Genomic_DNA.
DR RefSeq; WP_012669978.1; NC_012225.1.
DR AlphaFoldDB; C0QY54; -.
DR SMR; C0QY54; -.
DR STRING; 565034.BHWA1_00430; -.
DR EnsemblBacteria; ACN82926; ACN82926; BHWA1_00430.
DR GeneID; 63961517; -.
DR KEGG; bhy:BHWA1_00430; -.
DR eggNOG; COG0715; Bacteria.
DR HOGENOM; CLU_060267_0_0_12; -.
DR OMA; DIGHSEG; -.
DR Proteomes; UP000001803; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR SMART; SM00062; PBPb; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 23..346
FT /note="Putative ABC transporter periplasmic binding protein
FT BHWA1_00430"
FT /id="PRO_0000380707"
FT LIPID 23
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 23
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CONFLICT 153
FT /note="A -> S (in Ref. 1; ACD74824)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 37347 MW; 607E3F03436ABD12 CRC64;
MRKTVKIITS LVLIACLFLL ASCANKGSSS SGDATTLKVA VMPFLNSVPI EYMINNKLDE
KYGFKIETVY FPSGGPMNEA LGAGLWEVGT LSAASVYSLA NYNAHVVADI GHSEGGIEVL
VNPDSDILTV KGVNKDFPEV YGDAATLKGK TIAVPTGTIS HLNVIHWLRA INVDPNTVNI
VHMEFPQAYQ ALKAKKIDAA ALNPPTSFSA EADGMKIVSS LTTLNIPQYD SIIVSDEAFN
NKKDTIVLYI KAFLEACDAL QADPNMAAQE LLNWYTKNGS TSTLEACQSE VQTRPFVTTE
EIKNIKTGDS VRITADFFAS QSLITEDKLT VVDQNVDTEL LGKALN
