Y0436_DICDI
ID Y0436_DICDI Reviewed; 967 AA.
AC Q54FR9;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Probable serine/threonine-protein kinase DDB_G0290621;
DE EC=2.7.11.1;
GN ORFNames=DDB_G0290621;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000164; EAL62171.1; -; Genomic_DNA.
DR RefSeq; XP_635698.1; XM_630606.1.
DR AlphaFoldDB; Q54FR9; -.
DR SMR; Q54FR9; -.
DR STRING; 44689.DDB0220436; -.
DR PaxDb; Q54FR9; -.
DR PRIDE; Q54FR9; -.
DR EnsemblProtists; EAL62171; EAL62171; DDB_G0290621.
DR GeneID; 8627769; -.
DR KEGG; ddi:DDB_G0290621; -.
DR dictyBase; DDB_G0290621; -.
DR eggNOG; KOG0192; Eukaryota.
DR HOGENOM; CLU_306405_0_0_1; -.
DR InParanoid; Q54FR9; -.
DR OMA; HINGSYL; -.
DR PRO; PR:Q54FR9; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..967
FT /note="Probable serine/threonine-protein kinase
FT DDB_G0290621"
FT /id="PRO_0000355154"
FT DOMAIN 345..610
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 65..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..94
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 467
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 351..359
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 368
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 967 AA; 110461 MW; 2085D96990E562C9 CRC64;
MNSFEKKILI LKKDDKDSFI ALVKQLSTKE KQILFDTIDS RIRKLQTIYL NKPFNLKFLQ
TFIKEDSDED DDDEEDEEDE EDSDEEEDDD VVEDDNTKDI GKSRDSDKSI KGKEKGKEKE
KEEIEIIEQR YETKVIPKKP IYKDQQQELL QQLQLQQLQQ KPISPIKDNS GVSYNTSFSS
LSSLSMSNST SSSLLSTSLL SASLLSASSS GLSTSSLSSS INNSSNNNSN ISSSPLSSSP
LTLSSSSSSS SPLQRIQSIQ NLIRSNSLRT SLSSSSSLLP NLIQLQQQQL PPPPPSQQQQ
QQQQQQQQQN NSMLQQSNNN NISPRTQLLN NTTTLLPNNG LEEIFNDSNK IGEGGQCSIY
KYMGTAMKRF KPSLSSSLIS KEFENEVLIL ERLNHPNIVK IITYSTIERI ILLEFIDGNS
LDKYPSQSLP LSPSSSLPNP LKVIQDFQQI VDAMIYLHNE IGIIHFDLKP SNILKNSKNN
KLKLIDFGIS KFLNNNNQNN NNNSLNMGSY RYSPPELLCN NNQNNNLINK SVDVFSFGIM
LWECLNWTLP YESLSREQVK QIKTDMERES HLPLDHLPKG IQDLIRLCWK HDPSIRPSFI
EIRSRLSEII LNNIPSLNGR QFWISSSKYL QQNDDSLINN NNNNNQNNNN QNNNNNNNNN
NNNNNNNKDE TTSIIIYESI PWLKFKTFLS NHLNIYRQSS TSNSNSSFNL NNNSSRNNQR
QQQQQNNRNR SVYNNNYNNN NNNIINNNNN NINNNRNRNY NAYYEYIFDY IRYILKVIDE
KRDEVSVIEF SRFCTFFSPL ISSSLFRSIQ IFCDIPGLYG YCLKKDLILS SSMITLMSKI
GYLIFIDPNN INQLFLKMKA PTSSSSNKNN NNNNNDNNNP SNFIDFTIRV KIGNYNQRIF
QCHGHTSSSL SGLIKELQPL IDNNNSGNSS GSSSSKKSNS GFLYQKTPIS EIKDRHINGS
YLNQNYK
