ID   Y043_HAEI8              Reviewed;         551 AA.
AC   Q4QPK9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative transport protein NTHI0043 {ECO:0000255|HAMAP-Rule:MF_01016};
GN   OrderedLocusNames=NTHI0043;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01016};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01016}.
CC   -!- SIMILARITY: Belongs to the AAE transporter (TC 2.A.81) family. YidE
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01016}.
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DR   EMBL; CP000057; AAX87038.1; -; Genomic_DNA.
DR   RefSeq; WP_011271789.1; NC_007146.2.
DR   AlphaFoldDB; Q4QPK9; -.
DR   EnsemblBacteria; AAX87038; AAX87038; NTHI0043.
DR   KEGG; hit:NTHI0043; -.
DR   HOGENOM; CLU_035023_3_1_6; -.
DR   OMA; AMWLIRL; -.
DR   OrthoDB; 1458740at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 2.
DR   HAMAP; MF_01016; YidE; 1.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR023018; Transpt_YidE_put.
DR   InterPro; IPR006512; YidE_YbjL.
DR   Pfam; PF06826; Asp-Al_Ex; 2.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; SSF116726; 2.
DR   TIGRFAMs; TIGR01625; YidE_YbjL_dupl; 2.
DR   PROSITE; PS51202; RCK_C; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..551
FT                   /note="Putative transport protein NTHI0043"
FT                   /id="PRO_0000226891"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        402..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        492..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   TRANSMEM        529..549
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   DOMAIN          191..275
FT                   /note="RCK C-terminal 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
FT   DOMAIN          277..360
FT                   /note="RCK C-terminal 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01016"
SQ   SEQUENCE   551 AA;  59098 MW;  1CF9DAB520C2FADA CRC64;
     MSDIAITISL LALVAVIGLW IGHWKIRGVG LGIGGVLFGG IIVAHFTNQY GLKLDAHTLH
     FVQEFGLILF VYTIGIQVGP GFFSSLRKSG LKLNAFAILI IVLGSIAVVL VHKIADVPLD
     IALGIYSGAV TNTPALGAGQ QILAELGVPQ TTVTMGVSYA MAYPFGICGI LLAMWLIRLF
     FKVKVDDEAA RFNAESSQDK ESLHNISLKV TNQNLDGLTL IQIPGFSDEE VVCSRLKRDD
     MEIVPKASTE IRINDILQLV GDDNSLAKMR LIIGYEVDAP TVAYSGEIRS ERVVVTNEKV
     LGKKIRALGI HQKYGVVISR LNRAGIELVP TGNTTLQFGD VLHMVGRSDV LNQAISVIGN
     AQQKLLQVQM LPVFIGIGLG VLVGSIPFYI PGFPVALKLG LAGGPLVVAL ILARIGTIGK
     LYWFMPPSAN LALREIGIVL FLAVVGLKSG GSFFDTLVNG SGLEWMGYGI FITFIPLMIT
     GILARLYGKL NYLTICGLLA GSMTDPPALA FANEIKEDNG AAALSYATVY PLVMFLRIMS
     PQLLAVLLWA A