ID   Y043_MYCTO              Reviewed;         244 AA.
AC   P9WMG8; L0T2E2; P67737; P71700;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT0049;
GN   OrderedLocusNames=MT0049;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK44271.1; -; Genomic_DNA.
DR   PIR; C70912; C70912.
DR   RefSeq; WP_003899786.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMG8; -.
DR   SMR; P9WMG8; -.
DR   EnsemblBacteria; AAK44271; AAK44271; MT0049.
DR   GeneID; 45424002; -.
DR   KEGG; mtc:MT0049; -.
DR   PATRIC; fig|83331.31.peg.49; -.
DR   HOGENOM; CLU_017584_5_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT0049"
FT                   /id="PRO_0000427306"
FT   DOMAIN          7..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   244 AA;  27328 MW;  39BC96246E5F58BB CRC64;
     MPKKYGVKEK DQVVAHILNL LLTGKLRSGD RVDRNEIAHG LGVSRVPIQE ALVQLEHDGI
     VSTRYHRGAF IERFDVATIL EHHELDGLLN GIASARAAAN PTPRILGQLD AVMRSLRNSK
     ESRAFAECVW EYRRTVNDEY AGPRLHATIR ASQNLIPRVF WMTYQNSRDD VLPFYEEENA
     AIHRREPEAA RAACIGRSEL MAQTMLAELF RRRVLVPPEG ACPGPFGAPI PGFARSYQPS
     SPVP