Y0444_DICDI
ID Y0444_DICDI Reviewed; 1360 AA.
AC Q55BM1;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Probable inactive protein kinase DDB_G0270444;
GN ORFNames=DDB_G0270444;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP PROTEIN SEQUENCE OF 72-81; 201-211; 358-371; 628-637; 654-669 AND 675-699,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RA Bienvenut W.V., Veltman D.M., Insall R.H.;
RL Submitted (JAN-2010) to UniProtKB.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72572.1; -; Genomic_DNA.
DR RefSeq; XP_646809.1; XM_641717.1.
DR AlphaFoldDB; Q55BM1; -.
DR SMR; Q55BM1; -.
DR STRING; 44689.DDB0230126; -.
DR PaxDb; Q55BM1; -.
DR EnsemblProtists; EAL72572; EAL72572; DDB_G0270444.
DR GeneID; 8617795; -.
DR KEGG; ddi:DDB_G0270444; -.
DR dictyBase; DDB_G0270444; -.
DR eggNOG; KOG0275; Eukaryota.
DR eggNOG; KOG0660; Eukaryota.
DR HOGENOM; CLU_257077_0_0_1; -.
DR InParanoid; Q55BM1; -.
DR OMA; SIYVIME; -.
DR PRO; PR:Q55BM1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0018107; P:peptidyl-threonine phosphorylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1360
FT /note="Probable inactive protein kinase DDB_G0270444"
FT /id="PRO_0000377489"
FT REPEAT 44..83
FT /note="WD 1"
FT REPEAT 109..152
FT /note="WD 2"
FT REPEAT 166..205
FT /note="WD 3"
FT REPEAT 208..247
FT /note="WD 4"
FT DOMAIN 636..954
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 959..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1014..1269
FT /evidence="ECO:0000255"
FT COILED 1297..1352
FT /evidence="ECO:0000255"
FT COMPBIAS 1258..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1354
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1360 AA; 157740 MW; 8F3DC65CB58E91EB CRC64;
MGNQQSSGIE GSKPISAFYY NNISTVISRD GFYFFNNQSQ RFESSKRPIT FVIYDEEGNQ
FITGEDDFFI RLYNEDGTYI KQLPNLQSNI TTDVIAISHQ DFIRVLFPIR NIDFHQINSN
SNNSNTMLLS GGMDGTIRLW QVETGSLLAV YNQDISKVTM NGIIDTTSAG ITALTFDPTN
LLVISGTSDG IVRKHSLRER VIMGTFIGHS RGAILNLLLT KHGHLLSSSM DRTIRLWDID
SGKQITGCKY FSQTMVYDHH RDIVFAASDT GTIAVIQIVK DLNNSWSLKK IKVLDLKKPA
ILHLHYNTYV DQLTVTSIET NIASVQNATG IPFESVENDY KKQVNLVQGL WETTNNRLTI
TPSQSNNSLA KSQSINNQLN QSTTSTINQQ QQQQQQQQQQ QQQQQQQQQQ YEDEFEDEYI
DNQIKEKQQQ LLQQQQQQQQ QQQNEEEPIE DYIFSNEISS ELTEEFIQLS IEELKNIKLT
NMIENTLNSD QMILIDRLKQ LEFLGNELFE HQSSQEEKEY NEARKLKYVN GLTQFQDSIE
EMSEDYVSCM RMLIKTNDAD IVLDTDNCKD IKIRSLEQKR MEILERHRLE LEQFQGEVDR
ELSVFSDQQL PLITKKVANE CFENKKRLLN SQESIEKSIQ TYLSNTFPAV NQRYHLGPLI
SENSTTVFRA FDCKSLIPVA VKVLPPVALN IPVHENLTKV YQVCQTPQSI YVIMEPSTTS
LKPLVESMDQ HQLPISMVIS IMKQLLQCLL FLHSSSLVYR DLNPSRVLLT TTTTTANDDV
DCELQQQQQQ QVKVKLTHFG IMRSLQGNVD SEPAEDGMIY GSPEIFGRVI NTESDIWSLG
VIFIYLLQTK QERTKPLFHG HNNKSVIESI VKIVGRPFQK DIDRMIANGN MTSDAIQLLQ
YAASLPVPFE DSIDNLRSHC SLASDSALDL LTQMLQFVPH KRISIEQALS HPFILNLPKQ
QQQQQQQKQQ QQQQQQQQQE IIPKDDSLTD ISSNKQETVV YDANIQINQE DLISKIKENE
IQKEIDFKEN QINEEIKEDV KEEIEEDIKE EIKEEIKEES KEVQEEAKEE IKEEIQIETQ
EVKEEIKEEV QVEIKEEKIK EEIKEEIKEE TQEEIKEENK DEIQETIKEE VQVEIKEEIK
EETQEEIKEI LNEVQVKEEV KEEIQEEVSQ ETLSEIQEEV KEEIQEDIKE EVKEEIQNEI
REEIQNEIRE EIKEEIKKVS EEIQNEIQEE VKEEIQNEIQ EEQQDTIKEE IQEIKQEIIS
ERDTNQEGEI SDTIVSDSKE ADSIIEGPVT LERDNKNASD HDDEQQFVEE EIEVEEEIEV
EEEIEVEEEI EVEEEIEVEE EIEVEEEIQV EDDTDKSNDF
