ID   Y048_HAEIN              Reviewed;         285 AA.
AC   P44481;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized oxidoreductase HI_0048;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=HI_0048;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21726.1; -; Genomic_DNA.
DR   PIR; B64045; B64045.
DR   RefSeq; NP_438221.1; NC_000907.1.
DR   AlphaFoldDB; P44481; -.
DR   SMR; P44481; -.
DR   STRING; 71421.HI_0048; -.
DR   EnsemblBacteria; AAC21726; AAC21726; HI_0048.
DR   KEGG; hin:HI_0048; -.
DR   PATRIC; fig|71421.8.peg.48; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_1_6; -.
DR   OMA; QANLMTI; -.
DR   PhylomeDB; P44481; -.
DR   BioCyc; HINF71421:G1GJ1-49-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Uncharacterized oxidoreductase HI_0048"
FT                   /id="PRO_0000054841"
FT   ACT_SITE        181
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         168
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   285 AA;  30906 MW;  54440C3CD90595FC CRC64;
     MEFTMNIAAN HNLENKLIII TGAGGVLCSF LAKQLAYTKA NIALLDLNFE AADKVAKEIN
     QSGGKAKAYK TNVLELENIK EVRNQIETDF GTCDILINGA GGNNPKATTD NEFHQFDLNE
     TTRTFFDLDK SGIEFVFNLN YLGSLLPTQV FAKDMLGKQG ANIINISSMN AFTPLTKIPA
     YSGAKAAISN FTQWLAVYFS KVGIRCNAIA PGFLVSNQNL ALLFDTEGKP TDRANKILTN
     TPMGRFGESE ELLGALLFLI DENYSAFVNG VVLPVDGGFS AYSGV