ID   Y048_MYCTU              Reviewed;         289 AA.
AC   P9WM87; L0T2E7; P71705;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Uncharacterized protein Rv0048c;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv0048c; ORFNames=MTCY21D4.11c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP42770.1; -; Genomic_DNA.
DR   PIR; H70912; H70912.
DR   RefSeq; NP_214562.1; NC_000962.3.
DR   RefSeq; WP_003907183.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WM87; -.
DR   STRING; 83332.Rv0048c; -.
DR   PaxDb; P9WM87; -.
DR   PRIDE; P9WM87; -.
DR   DNASU; 887027; -.
DR   GeneID; 887027; -.
DR   KEGG; mtu:Rv0048c; -.
DR   TubercuList; Rv0048c; -.
DR   eggNOG; ENOG50343CC; Bacteria.
DR   OMA; TYLIVEP; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR012551; DUF1707.
DR   Pfam; PF08044; DUF1707; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..289
FT                   /note="Uncharacterized protein Rv0048c"
FT                   /id="PRO_0000014065"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   289 AA;  30817 MW;  C2FC916EDCC7711B CRC64;
     MAKWLGAPLA RGVSTATRAK DSDRQDACRI LDDALRDGEL SMEEHRERVS AATKAVTLGD
     LQRLVADLQV ESAPAQMPAL KSRAKRTELG LLAAAFVASV LLGVGIGWGV YGNTRSPLDF
     TSDPGAKPDG IAPVVLTPPR QLHSLGGLTG LLEQTRKRFG DTMGYRLVIY PEYASLDRVD
     PADDRRVLAY TYRGGWGDAT SSAKSIADVS VVDLSKFDAK TAVGIMRGAP ETLGLKQSDV
     KSMYLIVEPV KDPTTPAALS LSLYVSSDYG GGYLVFAGDG TIKHVSYPS