ID   Y0574_MYCTO             Reviewed;         380 AA.
AC   P9WM78; L0T731; O53771; Q7D9L9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Probable polyglutamine synthesis accessory protein MT0602 {ECO:0000250|UniProtKB:P9WM79};
GN   OrderedLocusNames=MT0602;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- FUNCTION: Could be involved in the biosynthesis, transport or
CC       localization of poly-alpha-L-glutamine (PLG), a cell wall component.
CC       Contributes to stress tolerance and virulence.
CC       {ECO:0000250|UniProtKB:P9WM79}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   -!- SIMILARITY: Belongs to the CapA family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44825.1; -; Genomic_DNA.
DR   PIR; E70933; E70933.
DR   RefSeq; WP_003403008.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WM78; -.
DR   EnsemblBacteria; AAK44825; AAK44825; MT0602.
DR   KEGG; mtc:MT0602; -.
DR   PATRIC; fig|83331.31.peg.634; -.
DR   HOGENOM; CLU_038823_3_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   CDD; cd07381; MPP_CapA; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR019079; Capsule_synth_CapA.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF09587; PGA_cap; 1.
DR   SMART; SM00854; PGA_cap; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Stress response.
FT   CHAIN           1..380
FT                   /note="Probable polyglutamine synthesis accessory protein
FT                   MT0602"
FT                   /id="PRO_0000427351"
SQ   SEQUENCE   380 AA;  41547 MW;  5197A2C71A981EF6 CRC64;
     MAGNPDVVTV LLGGDVMLGR GVDQILPHPG KPQLRERYMR DATGYVRLAE RVNGRIPLPV
     DWRWPWGEAL AVLENTATDV CLINLETTIT ADGEFADRKP VCYRMHPDNV PALTALRPHV
     CALANNHILD FGYQGLTDTV AALAGAGIQS VGAGADLLAA RRSALVTVGH ERRVIVGSVA
     AESSGVPESW AARRDRPGVW LIRDPAQRDV ADDVAAQVLA DKRPGDIAIV SMHWGSNWGY
     ATAPGDVAFA HRLIDAGIDM VHGHSSHHPR PIEIYRGKPI LYGCGDVVDD YEGIGGHESF
     RSELRLLYLT VTDPASGNLI SLQMLPLRVS RMRLQRASQT DTEWLRNTIE RISRRFGIRV
     VTRPDNLLEV VPAANLTSKE