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Y0574_MYCTU
ID   Y0574_MYCTU             Reviewed;         380 AA.
AC   P9WM79; L0T731; O53771; Q7D9L9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Probable polyglutamine synthesis accessory protein Rv0574c {ECO:0000305};
GN   OrderedLocusNames=Rv0574c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [3]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [4]
RP   INDUCTION BY CARBON MONOXIDE (CO).
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA   Shiloh M.U., Manzanillo P., Cox J.S.;
RT   "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT   macrophage infection.";
RL   Cell Host Microbe 3:323-330(2008).
RN   [5]
RP   INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA   Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA   Agarwal A., Steyn A.J.;
RT   "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT   tuberculosis dormancy regulon.";
RL   J. Biol. Chem. 283:18032-18039(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [7]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=H37Rv;
RX   PubMed=25312955; DOI=10.1128/iai.02274-14;
RA   Garg R., Tripathi D., Kant S., Chandra H., Bhatnagar R., Banerjee N.;
RT   "The conserved hypothetical protein Rv0574c is required for cell wall
RT   integrity, stress tolerance, and virulence of Mycobacterium tuberculosis.";
RL   Infect. Immun. 83:120-129(2015).
CC   -!- FUNCTION: Could be involved in the biosynthesis, transport or
CC       localization of poly-alpha-L-glutamine (PLG), a cell wall component.
CC       Contributes to stress tolerance and virulence.
CC       {ECO:0000269|PubMed:25312955}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia), low levels of nitric oxide (NO),
CC       carbon monoxide (CO) and carbon dioxide (CO(2)). Expression peaks in
CC       the late log phase of growth. {ECO:0000269|PubMed:11416222,
CC       ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:18400743,
CC       ECO:0000269|PubMed:18474359, ECO:0000269|PubMed:25312955}.
CC   -!- DISRUPTION PHENOTYPE: Disruption mutant shows reduced PLG content in
CC       the cell wall, increased sensitivity to chemical and mechanical agents,
CC       reduction of biofilm formation and attenuated virulence.
CC       {ECO:0000269|PubMed:25312955}.
CC   -!- SIMILARITY: Belongs to the CapA family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43312.1; -; Genomic_DNA.
DR   PIR; E70933; E70933.
DR   RefSeq; NP_215088.1; NC_000962.3.
DR   RefSeq; WP_003403008.1; NZ_NVQJ01000036.1.
DR   AlphaFoldDB; P9WM79; -.
DR   STRING; 83332.Rv0574c; -.
DR   PaxDb; P9WM79; -.
DR   PRIDE; P9WM79; -.
DR   GeneID; 887721; -.
DR   KEGG; mtu:Rv0574c; -.
DR   TubercuList; Rv0574c; -.
DR   eggNOG; COG2843; Bacteria.
DR   OMA; LYGCGDF; -.
DR   PhylomeDB; P9WM79; -.
DR   PHI-base; PHI:4898; -.
DR   Proteomes; UP000001584; Chromosome.
DR   CDD; cd07381; MPP_CapA; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR019079; Capsule_synth_CapA.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF09587; PGA_cap; 1.
DR   SMART; SM00854; PGA_cap; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..380
FT                   /note="Probable polyglutamine synthesis accessory protein
FT                   Rv0574c"
FT                   /id="PRO_0000392686"
SQ   SEQUENCE   380 AA;  41547 MW;  5197A2C71A981EF6 CRC64;
     MAGNPDVVTV LLGGDVMLGR GVDQILPHPG KPQLRERYMR DATGYVRLAE RVNGRIPLPV
     DWRWPWGEAL AVLENTATDV CLINLETTIT ADGEFADRKP VCYRMHPDNV PALTALRPHV
     CALANNHILD FGYQGLTDTV AALAGAGIQS VGAGADLLAA RRSALVTVGH ERRVIVGSVA
     AESSGVPESW AARRDRPGVW LIRDPAQRDV ADDVAAQVLA DKRPGDIAIV SMHWGSNWGY
     ATAPGDVAFA HRLIDAGIDM VHGHSSHHPR PIEIYRGKPI LYGCGDVVDD YEGIGGHESF
     RSELRLLYLT VTDPASGNLI SLQMLPLRVS RMRLQRASQT DTEWLRNTIE RISRRFGIRV
     VTRPDNLLEV VPAANLTSKE
 
 
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