ID   Y061_MYCGE              Reviewed;         567 AA.
AC   P47307;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Major facilitator superfamily transporter MG061;
GN   OrderedLocusNames=MG061;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 311-530.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA   Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL   J. Bacteriol. 175:7918-7930(1993).
RN   [3]
RP   SEQUENCE REVISION TO 419, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA   Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA   Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT   "Essential genes of a minimal bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Not essential, it can be deleted.
CC       {ECO:0000269|PubMed:16407165}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; L43967; AAC71278.2; -; Genomic_DNA.
DR   EMBL; U01705; AAB01017.1; -; Genomic_DNA.
DR   PIR; G64206; G64206.
DR   RefSeq; WP_010869311.1; NC_000908.2.
DR   AlphaFoldDB; P47307; -.
DR   STRING; 243273.MG_061; -.
DR   EnsemblBacteria; AAC71278; AAC71278; MG_061.
DR   KEGG; mge:MG_061; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_033053_0_0_14; -.
DR   OrthoDB; 1217725at2; -.
DR   BioCyc; MGEN243273:G1GJ2-64-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011699; MFS_Mycoplasma.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07672; MFS_Mycoplasma; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..567
FT                   /note="Major facilitator superfamily transporter MG061"
FT                   /id="PRO_0000210404"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   567 AA;  62822 MW;  5317D288B3E9DE68 CRC64;
     MENKSQKKVS DLKLITLWII VIFGYLLFVV EWFVIDRISG KPTGILTQST TTLPQYSGWL
     SSFFTENAGQ IATSSTNWTI TLLRAVGSIL CGVVVLKFGY RYAVLIMMGI MCVCFPFLII
     GDPLNGHNQL TLLRPLSDSV KTQLSSLSSN LQVGQLLGPV MINGKTMLAD GTSVELIKGL
     DGNSIGTAAS ITGYALFIIF RSTIAIGGTT LVVYTQPAIA NLSSNRKKSI LSNANLWGFN
     IGIAVVFTPF LFEQVQQVAS QYWVYIMTVM ILVVFANLCL FLWFESKIDH IFPQKQTKEN
     MSLTTQPKSI DILKNKTTWK LIGVYGIVLI LIVNPLTPAW FSILQTVSPS GSNGLISTGV
     YTTGLATLAI FWVIGYALGF VVFSPFNKTI YDKKRWMHFL LTANIVVLLI IIMFAATLGI
     GSAAGFALIS IFSFIGGAFA WSLSSSNLIL PYEFKDYKKN ELPILFGFCW GFGYIAYTLF
     DITQSVFLQA PVLIQGKGTS ILPGVIVSIV FFLGLIALAN LIVKFFPACW IKDGDQLVQE
     MTRKWKLNEW QFVIANKQKN RYSELLK