ID   Y064_MYCTO              Reviewed;         979 AA.
AC   P9WFL4; L0T5K5; O53609;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   02-JUN-2021, entry version 27.
DE   RecName: Full=UPF0182 protein MT0070 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=MT0070;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; AE000516; AAK44294.1; -; Genomic_DNA.
DR   PIR; A70848; A70848.
DR   RefSeq; WP_010924181.1; NC_002755.2.
DR   EnsemblBacteria; AAK44294; AAK44294; MT0070.
DR   KEGG; mtc:MT0070; -.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..979
FT                   /note="UPF0182 protein MT0070"
FT                   /id="PRO_0000428518"
FT   TRANSMEM        19..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          894..953
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..946
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   979 AA;  107429 MW;  49BC803D37F10EDE CRC64;
     METGSPGKRP VLPKRARLLV TAGMGMLALL LFGPRLVDIY VDWLWFGEVG FRSVWITVLL
     TRLAIVAAVA LVVAGIVLAA LLLAYRSRPF FVPDEPQRDP VAPLRSAVMR RPRLFGWGIA
     VTLGVVCGLI ASFDWVKVQL FVHGGTFGIV DPEFGYDIGF FVFDLPFYRS VLNWLFVAVV
     LAFLASLLTH YLFGGLRLTT GRGMLTQAAR VQLAVFAGAV VLLKAVAYWL DRYELLSSGR
     KEPTFTGAGY TDIHAELPAK LVLVAIAVLC AVSFFTAIFL RDLRIPAMAA ALLVLSAILV
     GGLWPLLMEQ FSVRPNAADV ERPYIQRNIE ATREAYRIGG DWVQYRSYPG IGTKQPRDVP
     VDVTTIAKVR LLDPHILSRT FTQQQQLKNF FSFAEILDID RYRIDGELQD YIVGVREFSP
     KSLTGNQTDW INKHTVYTHG NGFVAAPANR VNAAARDAEN ISDSNSGYPI YAVSDIASLG
     SGRQVIPVEQ PRVYYGEVIA QADPDYAIVG GAPGSAPREY DTDTSKYTYT GAGGVSIGNW
     FNRTVFATKV AQHKFLFSRE IGSESKVLIH RDPKERVQRV APWLTTDDNP YPVVVNGRIV
     WIVDAYTTLD TYPYAQRSSL EGPVTSPTGI VRQGKQVSYV RNSVKATVDA YDGTVTLFQF
     DRDDPVLRTW MRAFPGTVKS EDQIPDELRA HFRYPEDLFE VQRSLLAKYH VDEPREFFTT
     NAFWSVPSDP TNDANATQPP FYVLVGDQQS AQPSFRLASA MVGYNREFLS AYISAHSDPA
     NYGKLTVLEL PTDTLTQGPQ QIQNSMISDT RVASERTLLE RSNRIHYGNL LSLPIADGGV
     LYVEPLYTER ISTSPSSSTF PQLSRVLVSV REPRTEGGVR VGYAPTLAES LDQVFGPGTG
     RVATXPGGDA ASAPPPGAGG PAPPQGVPPP RTTQPPAAPP RGPDVPPATV AELRETLADL
     RAVLDRLEKA IDAAETPGG