ID   Y064_MYCTU              Reviewed;         979 AA.
AC   P9WFL5; L0T5K5; O53609;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=UPF0182 protein Rv0064 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=Rv0064; ORFNames=MTV030.07;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; AL123456; CCP42786.1; -; Genomic_DNA.
DR   PIR; A70848; A70848.
DR   RefSeq; NP_214578.1; NC_000962.3.
DR   RefSeq; WP_010886064.1; NC_000962.3.
DR   AlphaFoldDB; P9WFL5; -.
DR   STRING; 83332.Rv0064; -.
DR   PaxDb; P9WFL5; -.
DR   GeneID; 886996; -.
DR   KEGG; mtu:Rv0064; -.
DR   PATRIC; fig|83332.12.peg.72; -.
DR   TubercuList; Rv0064; -.
DR   eggNOG; COG1615; Bacteria.
DR   OMA; HFRYPLD; -.
DR   PhylomeDB; P9WFL5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..979
FT                   /note="UPF0182 protein Rv0064"
FT                   /id="PRO_0000157723"
FT   TRANSMEM        19..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          898..948
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..946
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   979 AA;  107369 MW;  BFBA681BAC2D9C0E CRC64;
     METGSPGKRP VLPKRARLLV TAGMGMLALL LFGPRLVDIY VDWLWFGEVG FRSVWITVLL
     TRLAIVAAVA LVVAGIVLAA LLLAYRSRPF FVPDEPQRDP VAPLRSAVMR RPRLFGWGIA
     VTLGVVCGLI ASFDWVKVQL FVHGGTFGIV DPEFGYDIGF FVFDLPFYRS VLNWLFVAVV
     LAFLASLLTH YLFGGLRLTT GRGMLTQAAR VQLAVFAGAV VLLKAVAYWL DRYELLSSGR
     KEPTFTGAGY TDIHAELPAK LVLVAIAVLC AVSFFTAIFL RDLRIPAMAA ALLVLSAILV
     GGLWPLLMEQ FSVRPNAADV ERPYIQRNIE ATREAYRIGG DWVQYRSYPG IGTKQPRDVP
     VDVTTIAKVR LLDPHILSRT FTQQQQLKNF FSFAEILDID RYRIDGELQD YIVGVRELSP
     KSLTGNQTDW INKHTVYTHG NGFVAAPANR VNAAARGAEN ISDSNSGYPI YAVSDIASLG
     SGRQVIPVEQ PRVYYGEVIA QADPDYAIVG GAPGSAPREY DTDTSKYTYT GAGGVSIGNW
     FNRTVFATKV AQHKFLFSRE IGSESKVLIH RDPKERVQRV APWLTTDDNP YPVVVNGRIV
     WIVDAYTTLD TYPYAQRSSL EGPVTSPTGI VRQGKQVSYV RNSVKATVDA YDGTVTLFQF
     DRDDPVLRTW MRAFPGTVKS EDQIPDELRA HFRYPEDLFE VQRSLLAKYH VDEPREFFTT
     NAFWSVPSDP TNNANATQPP FYVLVGDQQS AQPSFRLASA MVGYNREFLS AYISAHSDPA
     NYGKLTVLEL PTDTLTQGPQ QIQNSMISDT RVASERTLLE RSNRIHYGNL LSLPIADGGV
     LYVEPLYTER ISTSPSSSTF PQLSRVLVSV REPRTEGGVR VGYAPTLAES LDQVFGPGTG
     RVATARGGDA ASAPPPGAGG PAPPQAVPPP RTTQPPAAPP RGPDVPPATV AELRETLADL
     RAVLDRLEKA IDAAETPGG