ID   Y065_MYCBO              Reviewed;         979 AA.
AC   Q7U2X8; A0A1R3XU74; X2BDX2;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=UPF0182 protein Mb0065 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=BQ2027_MB0065;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; LT708304; SIT98440.1; -; Genomic_DNA.
DR   RefSeq; NP_853734.1; NC_002945.3.
DR   RefSeq; WP_010950333.1; NC_002945.4.
DR   AlphaFoldDB; Q7U2X8; -.
DR   EnsemblBacteria; SIT98440; SIT98440; BQ2027_MB0065.
DR   PATRIC; fig|233413.5.peg.73; -.
DR   OMA; HFRYPLD; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..979
FT                   /note="UPF0182 protein Mb0065"
FT                   /id="PRO_0000157720"
FT   TRANSMEM        19..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          898..948
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..946
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   979 AA;  107429 MW;  9DDEC335F5A36CBD CRC64;
     METGSPGKRP VLPKRARLLV TAGMGMLALL LFGPRLVDIY VDWLWFGEVG FRSVWITVLL
     TRLAIVAAVA LVVAGIVLAA LLLAYRSRPF FVPDEPQRDP VAPLRSAVMR RPRLFGWGIA
     VTLGVVCGLI ASFDWVKVQL FVHGGTFGIV DPEFGYDIGF FVFDLPFYRS VLNWLFVAVV
     LAFLASLLTH YLFGGLRLTT GRGMLTQAAR VQLAVFAGAV VLLKAVAYWL DRYELLSSGR
     KEPTFTGAGY TDIHAELPAK LVLVAIAVLC AVSFFTAIFL RDLRIPAMAA ALLVLSAILV
     GGLWPLLMEQ FSVRPNAADV ERPYIQRNIE ATREAYRIGG DWVQYRSYPG IGTKQPRDVP
     VDVTTIAKVR LLDPHILSRT FTQQQQLKNF FSFAEILDID RYRIDGELQD YIVGVRELSP
     KSLTGNQTDW INKHIVYTHG NGFVAAPANR VNAAARDAEN ISDSNSGYPI YAVSDIASLG
     SGRQVIPVEQ PRVYYGEVIA QADPDYAIVG GAPGSAPREY DTDTSKYTYT GAGGVSIGNW
     FNRTVFATKF AQHKFLFSRE IGSESKVLIH RDPKERVQRV APWLTTDDNP YPVVVNGRIV
     WIVDAYTTLD TYPYAQRSSL EGPVTSPTGI VRQGKQVSYV RNSVKATVDA YDGTVTLFQF
     DRDDPVLRTW MRAFPGTVKS EDQIPDELRA HFRYPEDLFE VQRSLLAKYH VDEPREFFTT
     NAFWSVPSDP TNDANATQPP FYVLVGDQQS AQPSFRLASA MVGYNREFLS AYISAHSDPA
     NYGKLTVLEL PTDTLTQGPQ QIQNSMISDT RVASERTLLE RSNRIHYGNL LSLPIADGGV
     LYVEPLYTER ISTSPSSSTF PQLSRVLVSV REPRTEGGVR VGYAPTLAES LDQVFGPGTG
     RVATAPGGDA ASAPPPGAGG PAPPQAVPPP RTTQPPAAPP RGPDVPPATV AELRETLADL
     RAVLDRLEKA IDAAETPGG