ID   Y066_MYCTA              Reviewed;         979 AA.
AC   A5TYD5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=UPF0182 protein MRA_0066 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=MRA_0066;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; CP000611; ABQ71785.1; -; Genomic_DNA.
DR   RefSeq; WP_009937016.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5TYD5; -.
DR   STRING; 419947.MRA_0066; -.
DR   EnsemblBacteria; ABQ71785; ABQ71785; MRA_0066.
DR   KEGG; mra:MRA_0066; -.
DR   eggNOG; COG1615; Bacteria.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   OMA; HFRYPLD; -.
DR   OrthoDB; 170146at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..979
FT                   /note="UPF0182 protein MRA_0066"
FT                   /id="PRO_0000323477"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          898..948
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..946
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   979 AA;  107427 MW;  BFBA68B7DCC29C0E CRC64;
     METGSPGKRP VLPKRARLLV TAGMGMLALL LFGPRLVDIY VDWLWFGEVG FRSVWITVLL
     TRLAIVAAVA LVVAGIVLAA LLLAYRSRPF FVPDEPQRDP VAPLRSAVMR RPRLFGWGIA
     VTLGVVCGLI ASFDWVKVQL FVHGGTFGIV DPEFGYDIGF FVFDLPFYRS VLNWLFVAVV
     LAFLASLLTH YLFGGLRLTT GRGMLTQAAR VQLAVFAGAV VLLKAVAYWL DRYELLSSGR
     KEPTFTGAGY TDIHAELPAK LVLVAIAVLC AVSFFTAIFL RDLRIPAMAA ALLVLSAILV
     GGLWPLLMEQ FSVRPNAADV ERPYIQRNIE ATREAYRIGG DWVQYRSYPG IGTKQPRDVP
     VDVTTIAKVR LLDPHILSRT FTQQQQLKNF FSFAEILDID RYRIDGELQD YIVGVRELSP
     KSLTGNQTDW INKHTVYTHG NGFVAAPANR VNAAARDAEN ISDSNSGYPI YAVSDIASLG
     SGRQVIPVEQ PRVYYGEVIA QADPDYAIVG GAPGSAPREY DTDTSKYTYT GAGGVSIGNW
     FNRTVFATKV AQHKFLFSRE IGSESKVLIH RDPKERVQRV APWLTTDDNP YPVVVNGRIV
     WIVDAYTTLD TYPYAQRSSL EGPVTSPTGI VRQGKQVSYV RNSVKATVDA YDGTVTLFQF
     DRDDPVLRTW MRAFPGTVKS EDQIPDELRA HFRYPEDLFE VQRSLLAKYH VDEPREFFTT
     NAFWSVPSDP TNNANATQPP FYVLVGDQQS AQPSFRLASA MVGYNREFLS AYISAHSDPA
     NYGKLTVLEL PTDTLTQGPQ QIQNSMISDT RVASERTLLE RSNRIHYGNL LSLPIADGGV
     LYVEPLYTER ISTSPSSSTF PQLSRVLVSV REPRTEGGVR VGYAPTLAES LDQVFGPGTG
     RVATARGGDA ASAPPPGAGG PAPPQAVPPP RTTQPPAAPP RGPDVPPATV AELRETLADL
     RAVLDRLEKA IDAAETPGG