ID   Y0687_MYCTO             Reviewed;         275 AA.
AC   P9WGS6; L0T4F2; P95033; Q7D9F4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Uncharacterized NAD-dependent oxidoreductase MT0715;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT0715;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44941.1; -; Genomic_DNA.
DR   PIR; B70640; B70640.
DR   RefSeq; WP_003403468.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGS6; -.
DR   SMR; P9WGS6; -.
DR   EnsemblBacteria; AAK44941; AAK44941; MT0715.
DR   GeneID; 45424649; -.
DR   KEGG; mtc:MT0715; -.
DR   PATRIC; fig|83331.31.peg.763; -.
DR   HOGENOM; CLU_010194_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR023985; SDR_subfam_1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03971; SDR_subfam_1; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..275
FT                   /note="Uncharacterized NAD-dependent oxidoreductase MT0715"
FT                   /id="PRO_0000428310"
FT   ACT_SITE        173
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         20..22
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         41..42
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         80..81
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         107
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         177
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         206..208
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   275 AA;  29028 MW;  43E9EB57986474C3 CRC64;
     MSARGGSLHG RVAFVTGAAR AQGRSHAVRL AREGADIVAL DICAPVSGSV TYPPATSEDL
     GETVRAVEAE GRKVLAREVD IRDDAELRRL VADGVEQFGR LDIVVANAGV LGWGRLWELT
     DEQWETVIGV NLTGTWRTLR ATVPAMIDAG NGGSIVVVSS SAGLKATPGN GHYAASKHAL
     VALTNTLAIE LGEFGIRVNS IHPYSVDTPM IEPEAMIQTF AKHPGYVHSF PPMPLQPKGF
     MTPDEISDVV VWLAGDGSGA LSGNQIPVDK GALKY