ID   Y072_CHLTR              Reviewed;         619 AA.
AC   O84075;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Putative zinc metalloprotease CT_072;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=CT_072;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC67663.1; -; Genomic_DNA.
DR   PIR; B71559; B71559.
DR   RefSeq; NP_219575.1; NC_000117.1.
DR   RefSeq; WP_009872359.1; NC_000117.1.
DR   AlphaFoldDB; O84075; -.
DR   STRING; 813.O172_00400; -.
DR   EnsemblBacteria; AAC67663; AAC67663; CT_072.
DR   GeneID; 884110; -.
DR   KEGG; ctr:CT_072; -.
DR   PATRIC; fig|272561.5.peg.81; -.
DR   HOGENOM; CLU_025778_0_0_0; -.
DR   InParanoid; O84075; -.
DR   OMA; YSRIVGW; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 2.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Membrane; Metal-binding;
KW   Metalloprotease; Protease; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc.
FT   CHAIN           1..619
FT                   /note="Putative zinc metalloprotease CT_072"
FT                   /id="PRO_0000088437"
FT   TRANSMEM        103..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        593..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         20
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         24
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   619 AA;  69285 MW;  BFFF42E478AC3F3F CRC64;
     MTIIYFVLAA LALGFLILIH ELGHLLAAKA VGMSVESFSI GFGPALVRKK MGSVEYRIGA
     IPFGGYVRIK GMDRNDKDNS GDKEKTVYDI PEGFFSKSPW KRIFVLAAGP LANLLVAIFV
     FGILYFSGGR TKSFSEYTSI VGWVHPSLEQ QGLHAGDQIF FCNGQPYSGH KMAFSSSLLE
     RKLSLQGQHP AYFSESEAFS LEAPFNPNME GVPCLGASYL LYRGSDPLPE KSPLVDAGLS
     EGDRLVWMDG LLVFSGAQVS QMLNEKQSFL RVERQGKVVF VRQARVLAGD LTLTPYFKNE
     LIDCQYEAGL KGKWASLYTL PYIINGDGFV ESKVKLLNDE RVSLDYNLEL GDKIVAVDGI
     PVMSNADILR LVQDHRVSLI FQRMSPEQLT VLEQKAADQA FINSYDMDDL LRVAESVGEE
     REVSRLGDYR LVTRVQPRPW AHIYSEALLD KQRALASKFR DEQERRYYLE RIEAEKQRIS
     LGIPLKDLAV QYNPDPWVLM EESVSDSLKT VKALGMGRVS PQWLSGPVGI VRILHTGWSV
     GIPEALAWIG LISVNLAVLN LLPIPVLDGG YILLCLWEIL SRRRLNMRLV EKALVPFMIL
     LVLFFVFLTL QDLSRVFVG