Y073_MYCTU
ID Y073_MYCTU Reviewed; 330 AA.
AC P9WQK5; L0T5L5; O53618; Q7DAI2;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 39.
DE RecName: Full=Uncharacterized ABC transporter ATP-binding protein Rv0073;
GN OrderedLocusNames=Rv0073;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP PUPYLATION AT LYS-65, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=20066036; DOI=10.1371/journal.pone.0008589;
RA Festa R.A., McAllister F., Pearce M.J., Mintseris J., Burns K.E.,
RA Gygi S.P., Darwin K.H.;
RT "Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium
RT tuberculosis.";
RL PLoS ONE 5:E8589-E8589(2010).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Probably part of an ABC transporter complex. Probably
CC responsible for energy coupling to the transport system (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (Rv0073),
CC two transmembrane proteins (Rv0072) and a solute-binding protein.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AL123456; CCP42796.1; -; Genomic_DNA.
DR PIR; B70849; B70849.
DR RefSeq; NP_214587.1; NC_000962.3.
DR RefSeq; WP_003899801.1; NZ_NVQJ01000005.1.
DR AlphaFoldDB; P9WQK5; -.
DR SMR; P9WQK5; -.
DR STRING; 83332.Rv0073; -.
DR PaxDb; P9WQK5; -.
DR DNASU; 886977; -.
DR GeneID; 45424035; -.
DR GeneID; 886977; -.
DR KEGG; mtu:Rv0073; -.
DR TubercuList; Rv0073; -.
DR eggNOG; COG0664; Bacteria.
DR eggNOG; COG1136; Bacteria.
DR OMA; YTAMGIQ; -.
DR PhylomeDB; P9WQK5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR017911; MacB_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Isopeptide bond; Nucleotide-binding; Reference proteome;
KW Transport; Ubl conjugation.
FT CHAIN 1..330
FT /note="Uncharacterized ABC transporter ATP-binding protein
FT Rv0073"
FT /id="PRO_0000395860"
FT DOMAIN 4..242
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 210..330
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT CROSSLNK 65
FT /note="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain
FT with Q-Cter in protein Pup)"
FT /evidence="ECO:0000269|PubMed:20066036"
SQ SEQUENCE 330 AA; 35801 MW; 300D8216C09E675B CRC64;
MGDLSIQNLV VEYYSGGYAL RPINGLNLDV AAGSLVMLLG PSGCGKTTLL SCLGGILRPK
SGAIKFDEVD ITTLQGAELA NYRRNKVGIV FQAFNLVPSL TAVENVMVPL RSAGMSRRAS
RRRAEELLAR VNLAERMNHR PGDLSGGQQQ RVAVARAIAL DPPLILADEP TAHLDFIQVE
EVLRLIRELA DGERVVVVAT HDSRMLPMAD RVVELTPDFA ETNRPPETVH LQAGEVLFEQ
STMGDLIYVV SEGEFEIVHE LADGGEELVK VAGPGDYFGE IGVLFHLPRS ATVRARSDAT
AVGYTVQAFR ERLGVGGLRD LIEHRALAND
