ID   Y078_STAAS              Reviewed;         745 AA.
AC   Q6GD21;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator SAS0078;
GN   OrderedLocusNames=SAS0078;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
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DR   EMBL; BX571857; CAG41845.1; -; Genomic_DNA.
DR   RefSeq; WP_001188468.1; NC_002953.3.
DR   AlphaFoldDB; Q6GD21; -.
DR   SMR; Q6GD21; -.
DR   KEGG; sas:SAS0078; -.
DR   HOGENOM; CLU_017624_1_0_9; -.
DR   OMA; TNGRFFR; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..745
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   SAS0078"
FT                   /id="PRO_0000194631"
FT   DOMAIN          158..256
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        175..196
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        223..246
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   745 AA;  87864 MW;  E62BD00F69062A55 CRC64;
     MQRDYLIRVE TESMPDFKRL NGLMIGFVIK GEAHIYDENN MTQCNSGDIF IINHRDLYRF
     QLQQDGIICY IQFQMKYLAD KFDDAHCLYF HLTDATTTKN IHQLRNIMAR LVSTHIRHNE
     LSKLTEQQLV IQLLMHMIHY VPRTYHSNQS ILNDDKVNQV CDYIELHFHE DLSLSELSEY
     VGWSESHLSK KFTESLGVGF QHFLNTTRIE HAKLDLTYTD ETITDIALQN GFSSAASFAR
     TFKHFTHQTP KQYRGDRPAI TENQQSAQHN YHDRELILLL NDYIEEMNHF IEDIEKMNYK
     EIAFKPTNQQ LNQFNHIIQV GYLRNLLNTQ YQSQLLTCHH DFQVNEVLAY DVMPYIMKKL
     NAPFTYDAEI SNIFYDIDLC LDFLLDHNFS LTMHLNQYDS RDYIDAFKVF IHHVALHVSH
     RKDLKFNLYV TTLHNALIEM IDYFKALFPN GGLYIHLDQA TERHLPLLKR LEPHIDHFVF
     DANSNDAVDF NKMNDDEFKT ASQMIINKTN YFIDLIHRHN LKRPLILLNW NTLTGDTFIT
     NGEYFRGGII IEQLLKLSSK VEGIGYWLNY DLHVSHCKNE RDYMNSIELF HQYNGKRPVY
     FTALLFNKLT SNILYSDDTC IVTGTDSNFQ ILLYDAKHFN PYLALDNQMN MRATEMIHLN
     INALEEGMYK IKHFTLDKEN GALFNLWRKH HTIHGMDKDS IDYVNRMSFP KLEVYDIDIT
     DTLALNIKMI TNGIHLIEVK RYPSS