ID   Y0793_MYCTU             Reviewed;         101 AA.
AC   O86332; F2GNQ9; L0T4X2;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Putative monooxygenase Rv0793;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv0793;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS), PUTATIVE FUNCTION, AND SUBUNIT.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16496224; DOI=10.1007/s10969-005-9004-6;
RA   Lemieux M.J., Ference C., Cherney M.M., Wang M., Garen C., James M.N.;
RT   "The crystal structure of Rv0793, a hypothetical monooxygenase from M.
RT   tuberculosis.";
RL   J. Struct. Funct. Genomics 6:245-257(2005).
CC   -!- FUNCTION: Putative monooygenase that might be involved in antibiotic
CC       biosynthesis, or may act as reactive oxygen species scavenger that
CC       could help in evading host defenses.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:16496224}.
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DR   EMBL; AL123456; CCP43541.1; -; Genomic_DNA.
DR   PIR; D70710; D70710.
DR   RefSeq; NP_215308.1; NC_000962.3.
DR   RefSeq; WP_003404010.1; NZ_NVQJ01000035.1.
DR   PDB; 1Y0H; X-ray; 1.60 A; A/B=1-101.
DR   PDBsum; 1Y0H; -.
DR   AlphaFoldDB; O86332; -.
DR   SMR; O86332; -.
DR   STRING; 83332.Rv0793; -.
DR   PaxDb; O86332; -.
DR   DNASU; 885497; -.
DR   GeneID; 885497; -.
DR   KEGG; mtu:Rv0793; -.
DR   TubercuList; Rv0793; -.
DR   eggNOG; COG1359; Bacteria.
DR   InParanoid; O86332; -.
DR   OMA; PHFTAFR; -.
DR   PhylomeDB; O86332; -.
DR   EvolutionaryTrace; O86332; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IBA:GO_Central.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007138; ABM_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   Pfam; PF03992; ABM; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS51725; ABM; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..101
FT                   /note="Putative monooxygenase Rv0793"
FT                   /id="PRO_0000420880"
FT   DOMAIN          5..93
FT                   /note="ABM"
FT   STRAND          5..11
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   HELIX           15..17
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   HELIX           18..26
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   HELIX           29..34
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   STRAND          38..46
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   STRAND          52..60
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   HELIX           61..68
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   HELIX           71..77
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   HELIX           81..83
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   STRAND          84..86
FT                   /evidence="ECO:0007829|PDB:1Y0H"
FT   STRAND          89..97
FT                   /evidence="ECO:0007829|PDB:1Y0H"
SQ   SEQUENCE   101 AA;  11192 MW;  039D1B1EA1ACA6A0 CRC64;
     MTSPVAVIAR FMPRPDARSA LRALLDAMIT PTRAEDGCRS YDLYESADGG ELVLFERYRS
     RIALDEHRGS PHYLNYRAQV GELLTRPVAV TVLAPLDEAS A