ID   Y085_MYCTU              Reviewed;         220 AA.
AC   P9WM75; L0T2J6; P64681; Q10882;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Uncharacterized protein Rv0085;
GN   OrderedLocusNames=Rv0085; ORFNames=MTCY251.03;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP42810.1; -; Genomic_DNA.
DR   PIR; E70749; E70749.
DR   RefSeq; NP_214599.1; NC_000962.3.
DR   RefSeq; WP_003400661.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WM75; -.
DR   STRING; 83332.Rv0085; -.
DR   PaxDb; P9WM75; -.
DR   DNASU; 886973; -.
DR   GeneID; 886973; -.
DR   KEGG; mtu:Rv0085; -.
DR   TubercuList; Rv0085; -.
DR   eggNOG; COG4237; Bacteria.
DR   OMA; VFGYCLM; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038730; HyfE-like.
DR   PANTHER; PTHR38601; PTHR38601; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..220
FT                   /note="Uncharacterized protein Rv0085"
FT                   /id="PRO_0000103660"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  23042 MW;  CB76F31A2972FD3C CRC64;
     MSNANFSILV DFAAGGLVLA SVLIVWRRDL RAIVRLLAWQ GAALAAIPLL RGIRDNDRAL
     IAVGIAVLAL RALVLPWLLA RAVGAEAAAQ REATPLVNTA SSLLITAGLT LTAFAITQPV
     VNLEPGVTIN AVPAAFAVVL IALFVMTTRL HAVSQAAGFL MLDNGIAATA FLLTAGVPLI
     VELGASLDVL FAVIVIGVLT GRLRRIFGDA DLDKLRELRD