ID   Y0883_DICDI             Reviewed;         460 AA.
AC   Q54FG0;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0290883;
GN   ORFNames=DDB_G0290883;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000171; EAL62006.1; -; Genomic_DNA.
DR   RefSeq; XP_635511.1; XM_630419.1.
DR   AlphaFoldDB; Q54FG0; -.
DR   SMR; Q54FG0; -.
DR   STRING; 44689.DDB0238325; -.
DR   PaxDb; Q54FG0; -.
DR   EnsemblProtists; EAL62006; EAL62006; DDB_G0290883.
DR   GeneID; 8627878; -.
DR   KEGG; ddi:DDB_G0290883; -.
DR   dictyBase; DDB_G0290883; trafC.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54FG0; -.
DR   OMA; HISECEN; -.
DR   PhylomeDB; Q54FG0; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54FG0; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 4.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF00917; MATH; 1.
DR   Pfam; PF02176; zf-TRAF; 2.
DR   SMART; SM00061; MATH; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..460
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0290883"
FT                   /id="PRO_0000393763"
FT   DOMAIN          320..448
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         27..67
FT                   /note="RING-type; degenerate"
FT   ZN_FING         141..194
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         196..253
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
SQ   SEQUENCE   460 AA;  53395 MW;  4F95ABE5F63E0644 CRC64;
     MSIDIKFTIN DILFNQESLQ KKNKYTCPIC FEFIYKKQIY QCKSGHHACK ECWEKSLETK
     KECMTCKSVV NSYNDLSRCL MVERAFDKKE CCCIYSFTEQ IVQGGTNCSP PDGASDQNQR
     KLIKDEENGC KEKIEVDQID SHLINCQYKF VTCSFKGCEK ILRMNSLESH QNECGFKLVI
     CDFCKRDDIK KKELETHYKT CPMVPIDCSQ GCSVKIERKS IIDHIENDCC NTQIPCKYFE
     QGCKVEMKRS ELQNHLERVN HQTYMGILID KLTNQVGHSK KTHDELLKKI EDLSLLIIKF
     SDACLKKQVL PKALDICSNG YRNKWIISNY SSLAKSKLNC KSLSSPILLI LSHHFQVCVY
     PKGDENKEYI SLYLRVNNIE EPNSLKVEYS FTLVNVLDKS KSITKRVDKI VFISPKEWGW
     GKFLLSDLIN KENGWLSNDD KLTIEIYIKI LNEEYEPLES