ID   Y0931_DICDI             Reviewed;         511 AA.
AC   Q54FD5;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0290931;
GN   ORFNames=DDB_G0290931;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000172; EAL61981.1; -; Genomic_DNA.
DR   RefSeq; XP_635487.1; XM_630395.1.
DR   AlphaFoldDB; Q54FD5; -.
DR   SMR; Q54FD5; -.
DR   STRING; 44689.DDB0252617; -.
DR   PaxDb; Q54FD5; -.
DR   PRIDE; Q54FD5; -.
DR   EnsemblProtists; EAL61981; EAL61981; DDB_G0290931.
DR   GeneID; 8627903; -.
DR   KEGG; ddi:DDB_G0290931; -.
DR   dictyBase; DDB_G0290931; trafL.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54FD5; -.
DR   OMA; IRVYESE; -.
DR   PhylomeDB; Q54FD5; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54FD5; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF00917; MATH; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   SMART; SM00061; MATH; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..511
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0290931"
FT                   /id="PRO_0000393759"
FT   DOMAIN          374..499
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         27..67
FT                   /note="RING-type; degenerate"
FT   ZN_FING         181..234
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         236..293
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   REGION          107..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          103..169
FT                   /evidence="ECO:0000255"
FT   COILED          324..358
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        107..152
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  60170 MW;  D4A7B5934C38528D CRC64;
     MSIYSKFTIN DVLLNKESLQ KKNKYTCPIC FELIYKKSIY QCSSGHYACQ ECWEKSLEIK
     QECMICRCKV KSFKNLSRCL VIEQNFSKKE CNCIYSFHLD YFIDGANQEN EDEENEDEEN
     EDDEDENEDE ENGEDDEDKD EDEENENENE ENKDEENEKR KLIKDEENGC KEIINVDQLD
     RHIQNCKFKF VKCSHIGCDR VLRLNSLKEH ENQCGFKLVK CEYCACDGII QVQLENHYDE
     CPKFVIGCPQ GCLNFFERDQ IKSHIENDCN NSTIQCKYYE YGCKVEMKRS ELQRHLENVN
     HQLFMGKLID KLSSTLDQSM KIQELLLKEI EKSKITCSEL QRKNDELSSL ITEIDDNYFN
     KNDFINSWKL TSQGYTNKWI ISNYSNLVEN TPHPEYIYSP SFDIVSREFV ISIYPNGSLT
     GKDHLSLFLH NNNEDPNKLE FTLELVNLLD KSKSITRKGL EVFEEIERKG WSKFLASKLI
     NKKNGWLSDD DKLTINIYVK ILYDDIEPLE S