ID   Y093_MYCS2              Reviewed;         317 AA.
AC   A0QNM1; I7FCF8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_0093;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MSMEG_0093, MSMEI_0091;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK70224.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AFP36573.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000480; ABK70224.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP001663; AFP36573.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_884509.1; NC_008596.1.
DR   AlphaFoldDB; A0QNM1; -.
DR   SMR; A0QNM1; -.
DR   STRING; 246196.MSMEI_0091; -.
DR   EnsemblBacteria; ABK70224; ABK70224; MSMEG_0093.
DR   EnsemblBacteria; AFP36573; AFP36573; MSMEI_0091.
DR   KEGG; msg:MSMEI_0091; -.
DR   KEGG; msm:MSMEG_0093; -.
DR   PATRIC; fig|246196.19.peg.91; -.
DR   eggNOG; COG3315; Bacteria.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..317
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MSMEG_0093"
FT                   /id="PRO_0000361193"
FT   BINDING         134
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         163..164
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   317 AA;  34832 MW;  A8B85B36D56D1EBA CRC64;
     MRETPSVRSA RDSWGITESV GATALGVAAA RAAETAQADP LIRDEFAFLL VSAAGPTWAQ
     MAVSDPHWLG ADADARRIHE ISRNYQAVRT HYFDEYFSDV AHAGIRQVVI LAAGLDSRAF
     RLDWPAGTTV FEIDQPKVLE YKTATLDAHG AVAKARYVPV PADLRDDWPA ALVEAGFDPA
     QPTAWLAEGL LPYLPADAQD RLFELVGVNS APGSRIAVEA FNMSPERYTE ERRAQRRARG
     EQMRKQLDLD IDVDALMYTA DDRADAAQWL SEHGWQVEAV PSADEMARLG RPAAEADLAE
     FGMDGVLMRA RLDGERL