ID   CAPP_NOCFA              Reviewed;         923 AA.
AC   Q5YYG7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_00595};
DE            Short=PEPC {ECO:0000255|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_00595};
GN   Name=ppc {ECO:0000255|HAMAP-Rule:MF_00595}; OrderedLocusNames=NFA_19280;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC       for the tricarboxylic acid cycle. {ECO:0000255|HAMAP-Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00595};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00595};
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00595}.
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DR   EMBL; AP006618; BAD56774.1; -; Genomic_DNA.
DR   RefSeq; WP_011208459.1; NC_006361.1.
DR   AlphaFoldDB; Q5YYG7; -.
DR   SMR; Q5YYG7; -.
DR   STRING; 247156.NFA_19280; -.
DR   PRIDE; Q5YYG7; -.
DR   EnsemblBacteria; BAD56774; BAD56774; NFA_19280.
DR   GeneID; 61132710; -.
DR   KEGG; nfa:NFA_19280; -.
DR   eggNOG; COG2352; Bacteria.
DR   HOGENOM; CLU_006557_2_0_11; -.
DR   OMA; PWVFGWT; -.
DR   BioCyc; NFAR247156:NFA_RS09715-MON; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PTHR30523; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation; Lyase; Magnesium; Reference proteome.
FT   CHAIN           1..923
FT                   /note="Phosphoenolpyruvate carboxylase"
FT                   /id="PRO_0000166606"
FT   ACT_SITE        149
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00595"
FT   ACT_SITE        585
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00595"
SQ   SEQUENCE   923 AA;  100839 MW;  FE19067A3E1A9B9B CRC64;
     MTEPRIETEQ DATRPLRDDI RFLGGVLGDT IRDHEGPEVF DLIERVRIEA FRVRREEVGR
     SAVAEMLRGV DIAVALPLIR AFSYFVLLAN LAEDIQRDRR RAVHVAAGEP PQDSSLAATY
     RKLDAAALDA AAVADLLSDA LVSPVITAHP TETRRRTVFD AQTRITELMR ARQRATDPAE
     RAALESRIRR QVLSLWRTAL IRLARLRIQD EIAVGLRYYE LTLFDVIPAI NAEVRAALRA
     RWPGADLLAR PILRPGSWIG GDRDGNPYVT AEVVRHAATQ AAGVALRRYL AELVELAKTL
     SLSARLVPVT PRVAELAAAG YPDPATHGDE PYRRALHHIR VRLSATADRV LDAPVPEAVA
     EPDAQPYAGP REFLDDLDAI DASLRASGDG LLADDRLAAL RHAVETFGFH LQGLDMRQNS
     EVHEQVVAEL LAWAGVHPAY GDLPEDARVE LLAAELRTRR PLLGPHARLS EQAAKEVGIV
     RAAKQVVDTF GPEAVPNYII SMCTSVSDML EAALLLKEGG LLDPGAPEGS PSCTVNIVPL
     FETIEDLGAG AATLAAALEV PVYRELVAAA GMRQEVMLGY SDSNKDGGYL AANWALYRAE
     LDLVEVARKT GIRLRLFHGR GGTVGRGGGR SYDAILAQPA GAVRGALRLT EQGEVIAAKY
     AEPGAAHRNL ESLIAGTLES TLLDVEGLGA DAEPAYELMD ELAALARAAY ARLVHETPGF
     VEYFRQSTPV AEVGDLNIGS RPASRKPTNS VSDLRAIPWV MAWSQARVML PGWYGTGAAL
     EEWVGGDPGR LARLTDLYRR WPFFRTVLSN LAQVMAKSDL DIAARYAELV DDAALRDQIF
     GMIREEHART LRMHAAITGH DQLLADNRSL AESIHNRFPY LEPLNQMQVE LLRRLRSGDD
     SELVKRGILL TMNGLATALR NSG