Y095_MYCS2
ID Y095_MYCS2 Reviewed; 311 AA.
AC A0QNM2; I7G2G5;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_0095/MSMEI_0092;
DE EC=2.1.1.-;
GN OrderedLocusNames=MSMEG_0095, MSMEI_0092;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
CC -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR EMBL; CP000480; ABK69783.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP36574.1; -; Genomic_DNA.
DR RefSeq; WP_011726662.1; NZ_SIJM01000048.1.
DR RefSeq; YP_884510.1; NC_008596.1.
DR AlphaFoldDB; A0QNM2; -.
DR SMR; A0QNM2; -.
DR STRING; 246196.MSMEI_0092; -.
DR EnsemblBacteria; ABK69783; ABK69783; MSMEG_0095.
DR EnsemblBacteria; AFP36574; AFP36574; MSMEI_0092.
DR GeneID; 66738285; -.
DR KEGG; msg:MSMEI_0092; -.
DR KEGG; msm:MSMEG_0095; -.
DR PATRIC; fig|246196.19.peg.92; -.
DR eggNOG; COG3315; Bacteria.
DR OMA; PMDITEL; -.
DR OrthoDB; 847145at2; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR011610; CHP00027_methylltransferase.
DR InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF04072; LCM; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE 3: Inferred from homology;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..311
FT /note="Putative S-adenosyl-L-methionine-dependent
FT methyltransferase MSMEG_0095/MSMEI_0092"
FT /id="PRO_0000361194"
FT BINDING 134
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 163..164
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
SQ SEQUENCE 311 AA; 34557 MW; 2FA96068975C91F4 CRC64;
MSSLRTDDDT WDIATSVGST AVMVAAARAG ETERDDALIR DPYAKILVAG AGTGVWETVL
DSEFAAKIEN LDPEAAAIFA HMGNYQAVRT HFFDAYYREA ADAGIRQIVI LASGLDSRAY
RLDWPAGTTV YEIDQPKVLE YKSATLREHG IEPVAQRREV PVDLRFDWPT ALHDAGFDAS
LPTAWLAEGL LMYLPAEAQD RLFELVTELS APGSRIAVET AGVAATDRRE AMRERFKKFA
DQLNLSSALD IQELVYDDPD RADVAEWLDA HGWRARGVHA LDEMRRLDRL VELPDDPDRA
AFSTFVTAQR L
