ID   Y0965_DICDI             Reviewed;         575 AA.
AC   Q54FC5;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0290965;
GN   ORFNames=DDB_G0290965;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000174; EAL61913.1; -; Genomic_DNA.
DR   RefSeq; XP_635412.1; XM_630320.1.
DR   AlphaFoldDB; Q54FC5; -.
DR   STRING; 44689.DDB0252616; -.
DR   PaxDb; Q54FC5; -.
DR   PRIDE; Q54FC5; -.
DR   EnsemblProtists; EAL61913; EAL61913; DDB_G0290965.
DR   GeneID; 8627913; -.
DR   KEGG; ddi:DDB_G0290965; -.
DR   dictyBase; DDB_G0290965; trafM.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54FC5; -.
DR   OMA; PWPFKQT; -.
DR   PhylomeDB; Q54FC5; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54FC5; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 2.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50145; ZF_TRAF; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..575
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0290965"
FT                   /id="PRO_0000393766"
FT   DOMAIN          420..563
FT                   /note="MATH"
FT   ZN_FING         27..67
FT                   /note="RING-type; degenerate"
FT   ZN_FING         133..186
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         188..245
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   COILED          275..401
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   575 AA;  67494 MW;  7BEF53A6A4482F44 CRC64;
     MSINSKFTIN DVLLNIESLQ KKNKYSCPIC FEFIYKKSIF QCKSGHFACK ECWEKSLKIK
     KECMICRSKV NSINDLSRCL VIEQGFGKKE CYCIYSFNND HFIDYANLDE NITLVKDKEN
     GCKEIINIDQ LDRHIQNCKF KFVECSHNGC DVVLRLNSLK EHENQCGYKL VKCKYCACDD
     TIQKELENHN NECPKFPIGC PQSCSIMVER DQTQSHINND CNNSTIQCKY YEYGCKVEMK
     RSELQNHLNN VNHQYFMGIL IDKLSSKLIQ SHNIQDELVK KIEQSEKNQE ILNKEYDQSK
     VICENRSKII CDKHVKKIEQ LEKTQENLNK QFELSRIIGE NRSKIICDKL VKTIEKSEKN
     QENLYKEYER SKIICDKLVK KIEQLEKTQE NLNKQFELSR IICDKLQKQN DQLLSLNALK
     YKNEWIISDY SKIVKKNPKG SLLNSPSFQV NQNNFLKSQS LCNILQNIFH LSFYQNGLSR
     INKIAIFLMG KSIEGTNVEF ICKLVNVLDE TNSIKFKTQK LKDIDDLEWD WSWGRSYIID
     SNLITQENGW LTKDDKLTIE FKVKIFNNVN KPLES