ID   Y0971_DICDI             Reviewed;         445 AA.
AC   Q54FB9;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0290971;
GN   ORFNames=DDB_G0290971;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000174; EAL61916.1; -; Genomic_DNA.
DR   RefSeq; XP_635418.1; XM_630326.1.
DR   AlphaFoldDB; Q54FB9; -.
DR   SMR; Q54FB9; -.
DR   STRING; 44689.DDB0189177; -.
DR   PaxDb; Q54FB9; -.
DR   EnsemblProtists; EAL61916; EAL61916; DDB_G0290971.
DR   GeneID; 8627919; -.
DR   KEGG; ddi:DDB_G0290971; -.
DR   dictyBase; DDB_G0290971; trafE.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54FB9; -.
DR   PhylomeDB; Q54FB9; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54FB9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..445
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0290971"
FT                   /id="PRO_0000393760"
FT   DOMAIN          314..441
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         23..67
FT                   /note="RING-type; degenerate"
FT   ZN_FING         133..186
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         186..242
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   COILED          269..307
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   445 AA;  51600 MW;  2DED0A17DE457692 CRC64;
     MTVKYSINEL LVDHESLSDN FTCPICFDLY YSSSSKKEVF QCRDGHLACK SCWSDSLLNK
     KECMICRTPV NSMNELSRNR FIENEFLKKK VYCPNSFFFI ENVNVDDSSM NEALIRDESN
     GCKEIITVEA LEKHQVECQF RFEKCPFTGC DKILRLKQIA EHKIDCKFSS KYCLHCDKEI
     PGQLDAHALV CPKVRIQCTQ SESCKKSFPR EQLRLHIDQD CKFTIVKCKY CCLNNSKNES
     IDFKRFELAD HYEKVNHSFE MDKVINNQQL ELVECKNQIY QINNKYEKLL ERVIKLEQLS
     MDASNKLSLL PRFKNSIIFA TFSTHKLKRV NEGISTVPLD VGNNKFKLTL YPNGYDESNK
     GNISAYLYRV SINEPAVKVS FTFVFNNQDS RKNRTYRIQE YTFNGGATSG WGYPKTLKTV
     DVDSANGWLT DEDKLVIGLR IQVLP