ID   Y097_MYCTU              Reviewed;         289 AA.
AC   P9WG83; L0T5I4; P67755; Q10893;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Putative dioxygenase Rv0097;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv0097; ORFNames=MTCY251.16;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the TfdA dioxygenase family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP42822.1; -; Genomic_DNA.
DR   PIR; A70751; A70751.
DR   RefSeq; NP_214611.1; NC_000962.3.
DR   RefSeq; WP_003400786.1; NZ_NVQJ01000053.1.
DR   AlphaFoldDB; P9WG83; -.
DR   SMR; P9WG83; -.
DR   STRING; 83332.Rv0097; -.
DR   PaxDb; P9WG83; -.
DR   DNASU; 886942; -.
DR   GeneID; 45424062; -.
DR   GeneID; 886942; -.
DR   KEGG; mtu:Rv0097; -.
DR   TubercuList; Rv0097; -.
DR   eggNOG; COG2175; Bacteria.
DR   OMA; VWDNRSL; -.
DR   PhylomeDB; P9WG83; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.130.10; -; 1.
DR   InterPro; IPR042098; TauD-like_sf.
DR   InterPro; IPR003819; TauD/TfdA-like.
DR   Pfam; PF02668; TauD; 1.
PE   1: Evidence at protein level;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Putative dioxygenase Rv0097"
FT                   /id="PRO_0000194020"
FT   BINDING         97
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         99
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         260
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   289 AA;  32641 MW;  FD38D0283E0E9F95 CRC64;
     MTLKVKGEGL GAQVTGVDPK NLDDITTDEI RDIVYTNKLV VLKDVHPSPR EFIKLGRIIG
     QIVPYYEPMY HHEDHPEIFV SSTEEGQGVP KTGAFWHIDY MFMPEPFAFS MVLPLAVPGH
     DRGTYFIDLA RVWQSLPAAK RDPARGTVST HDPRRHIKIR PSDVYRPIGE VWDEINRTTP
     PIKWPTVIRH PKTGQEILYI CATGTTKIED KDGNPVDPEV LQELMAATGQ LDPEYQSPFI
     HTQHYQVGDI ILWDNRVLMH RAKHGSAAGT LTTYRLTMLD GLKTPGYAA