Y1028_ARATH
ID Y1028_ARATH Reviewed; 525 AA.
AC Q8RXR6; Q9SX46;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=BTB/POZ domain-containing protein At1g50280;
GN OrderedLocusNames=At1g50280; ORFNames=F14I3.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD50054.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007980; AAD50054.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32532.1; -; Genomic_DNA.
DR EMBL; AY080713; AAL85031.1; -; mRNA.
DR EMBL; BT003005; AAO22813.1; -; mRNA.
DR PIR; B96539; B96539.
DR RefSeq; NP_175446.2; NM_103912.3.
DR AlphaFoldDB; Q8RXR6; -.
DR SMR; Q8RXR6; -.
DR BioGRID; 26675; 1.
DR IntAct; Q8RXR6; 1.
DR STRING; 3702.AT1G50280.1; -.
DR PaxDb; Q8RXR6; -.
DR PRIDE; Q8RXR6; -.
DR EnsemblPlants; AT1G50280.1; AT1G50280.1; AT1G50280.
DR GeneID; 841450; -.
DR Gramene; AT1G50280.1; AT1G50280.1; AT1G50280.
DR KEGG; ath:AT1G50280; -.
DR Araport; AT1G50280; -.
DR TAIR; locus:2011882; AT1G50280.
DR eggNOG; ENOG502QPQT; Eukaryota.
DR HOGENOM; CLU_005994_8_0_1; -.
DR InParanoid; Q8RXR6; -.
DR OMA; VFYGSWN; -.
DR OrthoDB; 539292at2759; -.
DR PhylomeDB; Q8RXR6; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q8RXR6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RXR6; baseline and differential.
DR Genevisible; Q8RXR6; AT.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IPI:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF03000; NPH3; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..525
FT /note="BTB/POZ domain-containing protein At1g50280"
FT /id="PRO_0000409570"
FT DOMAIN 5..79
FT /note="BTB"
FT DOMAIN 200..466
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
SQ SEQUENCE 525 AA; 60034 MW; B98F73EA5E2005A5 CRC64;
MSPLNDLKIN LNGQYTFFLN QNVISKYSGS LRKMIKQSKK KRNKKKRIIT IEINDFPGGP
DGFELVSRFC YHNGEILIDV SNVSTLYCCS VFLGMSEKFC FSNLFLQTEK FLEEVFYGSW
SDIVSCLKNC EQVFFQADSY GLVDKLIFAA LNKISQNSDD FSSSSLSSFA SSLSPEMAKN
TSESDGRYIS RSVACGRSNE WWFEDMTNLS PKIILKLVMI IGAYKTNIKS LVLTRFLLHY
LKTKLQTKSR TTTELMRNKL EYSDLADTAV RGVISAGTRT FSCRKLFWIL RVLSSFSLSR
ESRIGLETLI GEMLEQATLD DLLISARGSR ESGFYNVDLV IRLLKVFVKN REEEEEESRE
RNMKEIGKLI DKYLREISPD QNLKVPKFLG VAESLPDSAR DCFDGVYRAI DIYLQSHPNL
TPQDRTEICR CLNYKKLTME TCKQLARNPK IPPEIAIEAL KSRCGNQEHT TSDVKVANKS
FSCRYSEEKK KPVVLHLEIT EKLAERLKTK GGYNLKVMDS FREGL
