Y102_MYCTU
ID Y102_MYCTU Reviewed; 661 AA.
AC P9WM63; L0T5I9; P64689; Q10897;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Uncharacterized protein Rv0102;
GN OrderedLocusNames=Rv0102; ORFNames=MTCY251.21;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: To M.leprae ML1998. {ECO:0000305}.
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DR EMBL; AL123456; CCP42827.1; -; Genomic_DNA.
DR PIR; F70751; F70751.
DR RefSeq; NP_214616.1; NC_000962.3.
DR RefSeq; WP_003900808.1; NZ_NVQJ01000053.1.
DR AlphaFoldDB; P9WM63; -.
DR STRING; 83332.Rv0102; -.
DR PaxDb; P9WM63; -.
DR DNASU; 886926; -.
DR GeneID; 886926; -.
DR KEGG; mtu:Rv0102; -.
DR TubercuList; Rv0102; -.
DR eggNOG; COG3336; Bacteria.
DR OMA; YVVYFTP; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019108; Caa3_assmbl_CtaG-rel.
DR InterPro; IPR008457; Cu-R_CopD.
DR Pfam; PF09678; Caa3_CtaG; 1.
DR Pfam; PF05425; CopD; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..661
FT /note="Uncharacterized protein Rv0102"
FT /id="PRO_0000103672"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 661 AA; 70357 MW; 68B3BB57D0066C57 CRC64;
MGTHGATKSA TSAVPTPRSN SMAMVRLAIG LLGVCAVVAA FGLVSGARRY AEAGNPYPGA
FVSVAEPVGF FAASLAGALC LGALIHVVMT AKPEPDGLID AAAFRIHLLA ERVSGLWLGL
AATMVVIQAA HDTGVGPARL LASGALSDSV AASEMARGWI VAAICALVVA TALRLYTRWL
GHVVLLVPTV LAVVATAVTG NPGQGPDHDY ATSAAIVFAV AFATLTGLKI AAALAGTTPS
RAVLVTQVTC GALALAYGAM LLYLFIPGWA VDSDFARLGL LAGVILTSVW LFDCWRLLVR
PPHAGRRRGG GSGAALAMMA AMASIAAMAV MTAPRFLTHA FTAWDVFLGY ELPQPPTIAR
VLTVWRFDSL IGAAGVVLAI GYAAGFAALR RRGNSWPVGR LIAWLTGCAA LVFTSGSGVR
AYGSAMFSVH MAEHMTLNMF IPVLLVLGGP VTLALRVLPV TGDGRPPGAR EWLTWLLHSR
VTTFLSHPIT AFVLFVASPY IVYFTPLFDT FVRYHWGHEF MAIHFLVVGY LFYWAIIGID
PGPRRLPYPG RIGLLFAVMP FHAFFGIALM TMSSTVGATF YRSVNLPWLS SIIADQHLGG
GIAWSLTELP VIMVIVALVT QWARQDRRVA SREDRHADSD YADDELEAYN AMLRELSRMR
R
