ID   Y1033_STRP8             Reviewed;         339 AA.
AC   Q8P171;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=UPF0324 membrane protein spyM18_1033;
GN   OrderedLocusNames=spyM18_1033;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0324 family. {ECO:0000305}.
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DR   EMBL; AE009949; AAL97663.1; -; Genomic_DNA.
DR   RefSeq; WP_011017723.1; NC_003485.1.
DR   AlphaFoldDB; Q8P171; -.
DR   KEGG; spm:spyM18_1033; -.
DR   HOGENOM; CLU_033541_2_1_9; -.
DR   OMA; FGLWCAI; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018383; UPF0324_pro.
DR   PANTHER; PTHR30106; PTHR30106; 1.
DR   Pfam; PF03601; Cons_hypoth698; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="UPF0324 membrane protein spyM18_1033"
FT                   /id="PRO_0000157467"
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   339 AA;  36165 MW;  CB03AC6B88BEA3D0 CRC64;
     MSTHLRKLPG LLLCLLLALP AWYLGRLFPI IGAPVFAILL GMLLALFYGH RDKTKEGISF
     TSKCILQTAV VLLGFGLNLT QVMAVGMQSL PIIISTIATA LLVAYGLQKW LRLDVNTATL
     VGVGSSICGG SAIAATAPVI KAKDDEVAKA ISVIFLFNML AALLFPSLGQ LLGLSNEGFA
     IFAGTAVNDT SSVTATATAW DAIHHSNTLD GATIVKLTRT LAILPITLGL SLYRAKKEHD
     IVTEENFSLR KSFPRFILFF LLASLITTLM TSFGVSAEVF HSLKTLSKFF IVMAMAAIGL
     NTNLVKLIKT GGQAILLGAI CWVAITLVSL AMQLSLGIW