ID   Y1037_TREPA             Reviewed;         238 AA.
AC   O84000;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=UPF0073 membrane protein TP_1037;
GN   OrderedLocusNames=TP_1037;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0073 (Hly-III) family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC26591.1; -; Genomic_DNA.
DR   PIR; D71250; D71250.
DR   AlphaFoldDB; O84000; -.
DR   SMR; O84000; -.
DR   IntAct; O84000; 5.
DR   STRING; 243276.TPANIC_1037; -.
DR   EnsemblBacteria; AAC26591; AAC26591; TP_1037.
DR   KEGG; tpa:TP_1037; -.
DR   eggNOG; COG1272; Bacteria.
DR   HOGENOM; CLU_051078_1_0_12; -.
DR   OMA; HEVFHSL; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   InterPro; IPR005744; Hy-lIII.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
DR   TIGRFAMs; TIGR01065; hlyIII; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..238
FT                   /note="UPF0073 membrane protein TP_1037"
FT                   /id="PRO_0000176904"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  26095 MW;  B74F7EB6CAFBECB1 CRC64;
     MEKIVNADGS DAICPASAAC AKSIRSYQES YSLGEEIANA VTHGIGVGLS IVALVLLVVR
     AVHYTPADLT ARYVVGFSVF GSSLIVLYLC STLYHALPRG AKYVFGVIDH CCIYVLIAGT
     YTASCLTTLY GAIGWTVFGV IWGLACSGSV IYSVFGHRVR WLSLVMYIAM GWLVVFVAKP
     LRERLPEISF LFLVLGGVLY TVGCVFYALK RIKWTHTIWH MFVIGGSVMH FFSLYLSF