ID   Y103_METJA              Reviewed;         433 AA.
AC   Q57567;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Uncharacterized protein MJ0103;
GN   OrderedLocusNames=MJ0103;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. {ECO:0000305}.
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DR   EMBL; L77117; AAB98083.1; -; Genomic_DNA.
DR   PIR; G64312; G64312.
DR   RefSeq; WP_010869595.1; NC_000909.1.
DR   AlphaFoldDB; Q57567; -.
DR   SMR; Q57567; -.
DR   STRING; 243232.MJ_0103; -.
DR   EnsemblBacteria; AAB98083; AAB98083; MJ_0103.
DR   GeneID; 1450944; -.
DR   KEGG; mja:MJ_0103; -.
DR   eggNOG; arCOG00951; Archaea.
DR   HOGENOM; CLU_048071_0_0_2; -.
DR   InParanoid; Q57567; -.
DR   OMA; CIFCSVD; -.
DR   OrthoDB; 68339at2157; -.
DR   PhylomeDB; Q57567; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR040088; MJ0103-like.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR002792; TRAM_dom.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01110; Uncharacterised_Radical_SAM_Su; 1.
DR   SMART; SM00729; Elp3; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
DR   PROSITE; PS50926; TRAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..433
FT                   /note="Uncharacterized protein MJ0103"
FT                   /id="PRO_0000171931"
FT   DOMAIN          104..349
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   DOMAIN          370..433
FT                   /note="TRAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00208"
FT   BINDING         118
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250"
FT   BINDING         122
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250"
FT   BINDING         125
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250"
FT   BINDING         171..172
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         236..238
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   433 AA;  49866 MW;  F82576531DF12142 CRC64;
     MVCLDLSQYR MITDVKNKDN TLILEINKIY EIEVEIPYEE VEIDGSIIKI NAHPKRAENI
     KVGILNLISY SIANNLKSKI TKRKTIYINE PIPLIGHTAF GLIERGRNII QVRGHCGCNL
     NCIFCSVDEG EFSKTRKNDY YVDLEYLIEN YKKIVDFKEN KFIEAHLDGQ GEPSLYYPLV
     DLVQELAEIN KKGNGIVSMQ TNGTVLNYKL IDELEEAGLH RINLSINALD EKMAKMLSGR
     RDYNIKKILD IAEYIKNSKI HLLIAPLLLP NINDEEFKRV IEYAVDLEQK NPQNIINPLT
     GKKDPILGCQ LCRVYQLGRR PKKMKVWDFE KFYYLLGKYE LEYKKKGIEV KLITSPKDFG
     THKRKRLPYP FKVGEVTKVK VVLDGRVKGE VLGVAKDRVI QIINCNNEQN LIGKTVKVRI
     LRNKDNIIVA ELV