ID   Y1044_HELPY             Reviewed;         370 AA.
AC   O25685;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Uncharacterized metallophosphoesterase HP_1044;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=HP_1044;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000511; AAD08089.1; -; Genomic_DNA.
DR   PIR; D64650; D64650.
DR   RefSeq; NP_207834.1; NC_000915.1.
DR   RefSeq; WP_000908758.1; NC_018939.1.
DR   AlphaFoldDB; O25685; -.
DR   SMR; O25685; -.
DR   PaxDb; O25685; -.
DR   DNASU; 899579; -.
DR   EnsemblBacteria; AAD08089; AAD08089; HP_1044.
DR   KEGG; hpy:HP_1044; -.
DR   PATRIC; fig|85962.47.peg.1123; -.
DR   eggNOG; COG1408; Bacteria.
DR   OMA; MQFGIEI; -.
DR   PhylomeDB; O25685; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008758; F:UDP-2,3-diacylglucosamine hydrolase activity; IBA:GO_Central.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Reference proteome.
FT   CHAIN           1..370
FT                   /note="Uncharacterized metallophosphoesterase HP_1044"
FT                   /id="PRO_0000172855"
FT   BINDING         152
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         154
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         184
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         184
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         215
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         306
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         308
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   370 AA;  42457 MW;  1392DC99BC70AE0C CRC64;
     MLISIAFLLV LYLLNYSSFR MLKSFLTLKK ISQYAYLWFF ILLSIGEAAF VFYRNIMPSH
     LFVLTSACSF VSFIIFILSL SFYGFSYSIE KIDFLHSRRK SLKNFLKLGF YLALLGYFWR
     GFYEGLARPK IKETPIYLDK LDKELKIILL TDMHVGSLLQ KDFVDYIVEE VNQKEVDMVL
     IGGDLVDESI EKVKSFLLPL NNLKSTHGTF YVPGNHEYYH GIEPILSFLD TLNLTILGNE
     CVHLGGINLC GVYDYFARKR QNFAPDIDKA LKKRNESKPT ILLAHQPKQI RSLKESHSVD
     LVLSGHTHAG QIFPFSLLVK LAQTYLHGLY KHSPTTQIYV SSGAGYWGIP LRFLAPSEIA
     YLRLLPKNQA