ID   Y104_MYCTU              Reviewed;         504 AA.
AC   P9WM61; L0T2G9; Q10898;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Uncharacterized protein Rv0104;
GN   OrderedLocusNames=Rv0104; ORFNames=MTCY251.23;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP42829.1; -; Genomic_DNA.
DR   PIR; H70751; H70751.
DR   RefSeq; NP_214618.1; NC_000962.3.
DR   RefSeq; WP_003899813.1; NZ_NVQJ01000053.1.
DR   AlphaFoldDB; P9WM61; -.
DR   SMR; P9WM61; -.
DR   STRING; 83332.Rv0104; -.
DR   PaxDb; P9WM61; -.
DR   DNASU; 886923; -.
DR   GeneID; 886923; -.
DR   KEGG; mtu:Rv0104; -.
DR   TubercuList; Rv0104; -.
DR   eggNOG; COG0499; Bacteria.
DR   eggNOG; COG0664; Bacteria.
DR   OMA; PRHERVD; -.
DR   PHI-base; PHI:3639; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   Gene3D; 3.40.50.1480; -; 1.
DR   InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..504
FT                   /note="Uncharacterized protein Rv0104"
FT                   /id="PRO_0000103675"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         372..492
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
SQ   SEQUENCE   504 AA;  53451 MW;  3FCF8A42EE75009F CRC64;
     MTPVTTFPLV DAILAGRDRN LDGVILIAAQ HLLQTTHAML RSLFRVGLDP RNVAVIGKCY
     STHPGVVDAM RADGIYVDDC SDAYAPHESF DTQYTRHVER FFAESWARLT AGRTARVVLL
     DDGGSLLAVA GAMLDASADV IGIEQTSAGY AKIVGCALGF PVINIARSSA KLLYESPIIA
     ARVTQTAFER TAGIDSSAAI LITGAGAIGT ALADVLRPLH DRVDVYDTRS GCMTPIDLPN
     AIGGYDVIIG ATGATSVPAS MHELLRPGVL LMSASSSDRE FDAVALRRRT TPNPDCHADL
     RVADGSVDAT LLNSGFPVNF DGSPMCGDAS MALTMALLAA AVLYASVAVA DEMSSDHPHL
     GLIDQGDIVA SFLNIDVPLQ ALSRLPLLSI DGYRRLQVRS GYTLFRQGER ADHFFVIESG
     ELEALVDGKV ILRLGAGDHF GEACLLGGMR RIATVRACEP SVLWELDGKA FGDALHGDAA
     MREIAYGVAR TRLMHAGASE SLMV