ID   Y1052_STRPN             Reviewed;         258 AA.
AC   Q97QZ0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Uncharacterized protein SP_1052;
GN   OrderedLocusNames=SP_1052;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [2]
RP   DISRUPTION PHENOTYPE, AND OPERON STRUCTURE.
RC   STRAIN=0100993 / NCIMB 40794 / Serotype 3;
RX   PubMed=14977965; DOI=10.1128/iai.72.3.1587-1593.2004;
RA   Brown J.S., Gilliland S.M., Spratt B.G., Holden D.W.;
RT   "A locus contained within a variable region of pneumococcal pathogenicity
RT   island 1 contributes to virulence in mice.";
RL   Infect. Immun. 72:1587-1593(2004).
CC   -!- INDUCTION: In S.pneumoniae strain 0100993 is found in the
CC       pezT/SP_1052/SP_1053 operon.
CC   -!- DISRUPTION PHENOTYPE: Strains with a pezT/SP_1052/SP_1053 disruption
CC       have partially attenuated virulence, they take longer to develop a
CC       terminal infection in mice, although they grow normally in liquid
CC       culture. A double SP_1052/SP_1053 disruption grows almost as well as
CC       wild-type, showing the effect is mostly due to disruption of pezT.
CC       {ECO:0000269|PubMed:14977965}.
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DR   EMBL; AE005672; AAK75166.1; -; Genomic_DNA.
DR   PIR; A97991; A97991.
DR   PIR; E95121; E95121.
DR   AlphaFoldDB; Q97QZ0; -.
DR   STRING; 170187.SP_1052; -.
DR   EnsemblBacteria; AAK75166; AAK75166; SP_1052.
DR   KEGG; spn:SP_1052; -.
DR   eggNOG; COG0613; Bacteria.
DR   OMA; QHLLTIM; -.
DR   Proteomes; UP000000585; Chromosome.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   SUPFAM; SSF89550; SSF89550; 1.
PE   2: Evidence at transcript level;
FT   CHAIN           1..258
FT                   /note="Uncharacterized protein SP_1052"
FT                   /id="PRO_0000410968"
SQ   SEQUENCE   258 AA;  30435 MW;  CCA078912E63B511 CRC64;
     MRGFNNKIKS VYQELTNSKE KFGSFHKTLI HLHTPVSYDY KLFSNWTATK YRKITEDELY
     DIFFENKKIK VDKTIFFSNF DKVVFSSSKE YISFLMLAEA IIKNGIEIVV VTDHNTTKGI
     KKLQMAVSII MKNYPIYDIH PHILHGVEIS AADKLHIVCI YDYEQESWVN QWLSENIISE
     KDGSYQHSLT IMKDFNNQKI VNYIAHFNSY DILKKGSHLS GAYKRKIFSK ENTRFWSLIL
     TRKNLRNNLI FSIKKLVY