ID   Y1053_STRPN             Reviewed;         125 AA.
AC   Q97QY9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Uncharacterized protein SP_1053;
GN   OrderedLocusNames=SP_1053;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [2]
RP   DISRUPTION PHENOTYPE, AND OPERON STRUCTURE.
RC   STRAIN=0100993 / NCIMB 40794 / Serotype 3;
RX   PubMed=14977965; DOI=10.1128/iai.72.3.1587-1593.2004;
RA   Brown J.S., Gilliland S.M., Spratt B.G., Holden D.W.;
RT   "A locus contained within a variable region of pneumococcal pathogenicity
RT   island 1 contributes to virulence in mice.";
RL   Infect. Immun. 72:1587-1593(2004).
CC   -!- INDUCTION: In S.pneumoniae strain 0100993 is found in the
CC       pezT/SP_1052/SP_1053 operon.
CC   -!- DISRUPTION PHENOTYPE: Strains with a pezT/SP_1052/SP_1053 disruption
CC       have partially attenuated virulence, they take longer to develop a
CC       terminal infection in mice, although they grow normally in liquid
CC       culture. A double SP_1052/SP_1053 disruption grows almost as well as
CC       wild-type, showing the effect is mostly due to disruption of pezT.
CC       {ECO:0000269|PubMed:14977965}.
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DR   EMBL; AE005672; AAK75167.1; -; Genomic_DNA.
DR   PIR; F95121; F95121.
DR   AlphaFoldDB; Q97QY9; -.
DR   STRING; 170187.SP_1053; -.
DR   EnsemblBacteria; AAK75167; AAK75167; SP_1053.
DR   KEGG; spn:SP_1053; -.
DR   eggNOG; COG1196; Bacteria.
DR   OMA; HGWISNS; -.
DR   Proteomes; UP000000585; Chromosome.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
FT   CHAIN           1..125
FT                   /note="Uncharacterized protein SP_1053"
FT                   /id="PRO_0000410969"
SQ   SEQUENCE   125 AA;  14473 MW;  382B93691E9923FA CRC64;
     MGQKVVAMLD FLLAYSDYSK DFRPLIIDQP EDNLDNRYIY RHLVQQFRDV KAQRQIILAT
     HNATIVTNSM TDQVVIMESD GVNGWIESQG YVSEKYIKNH IINQLEGGKD SFKHKMSIYE
     TALSE