ID   Y1054_METJA             Reviewed;         895 AA.
AC   Q58454;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Uncharacterized protein MJ1054;
DE            EC=1.1.1.-;
DE   Contains:
DE     RecName: Full=Mja UDPGD intein;
GN   OrderedLocusNames=MJ1054;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- PTM: This protein undergoes a protein self splicing that involves a
CC       post-translational excision of the intervening region (intein) followed
CC       by peptide ligation. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99056.1; -; Genomic_DNA.
DR   PIR; E64431; E64431.
DR   RefSeq; WP_010870567.1; NC_000909.1.
DR   AlphaFoldDB; Q58454; -.
DR   SMR; Q58454; -.
DR   STRING; 243232.MJ_1054; -.
DR   EnsemblBacteria; AAB99056; AAB99056; MJ_1054.
DR   GeneID; 1451951; -.
DR   KEGG; mja:MJ_1054; -.
DR   eggNOG; arCOG00253; Archaea.
DR   HOGENOM; CLU_320207_0_0_2; -.
DR   InParanoid; Q58454; -.
DR   OMA; IKWEFLK; -.
DR   OrthoDB; 47911at2157; -.
DR   PhylomeDB; Q58454; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR003586; Hint_dom_C.
DR   InterPro; IPR003587; Hint_dom_N.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR030934; Intein_C.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_N.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   Pfam; PF14528; LAGLIDADG_3; 2.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PRINTS; PR00379; INTEIN.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51294; SSF51294; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   SUPFAM; SSF55608; SSF55608; 2.
DR   TIGRFAMs; TIGR01443; intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; intein_Nterm; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
PE   3: Inferred from homology;
KW   Autocatalytic cleavage; NAD; Oxidoreductase; Protein splicing;
KW   Reference proteome.
FT   CHAIN           1..260
FT                   /note="Uncharacterized protein MJ1054, 1st part"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000035997"
FT   CHAIN           261..714
FT                   /note="Mja UDPGD intein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000035998"
FT   CHAIN           715..895
FT                   /note="Uncharacterized protein MJ1054, 2nd part"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000035999"
FT   DOMAIN          468..614
FT                   /note="DOD-type homing endonuclease"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00273"
FT   ACT_SITE        261
FT                   /evidence="ECO:0000250"
FT   BINDING         2..19
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   895 AA;  102615 MW;  B511AA68CCA41445 CRC64;
     MNISVIGTGY VGLIQAVGLA EFGFDVVGID IDESKVKALN RGECPLYEEG LEGLLKKHVN
     KNLTFTTSYK PIKDSDVIFL CVGTPQDKDG NADLRFLFSA VEKIKETIDK EDYKVIVIKS
     TVPVGTNRRV KELLKDYNVD VVSNPEFLRE GIAVYDFFNP ERVILGFENL NNKKPIEIME
     EVYKYFKDKN IPFVITNWET AELIKYASNA FLATKISFIN ELAKLSDKVK ADIKTISYAM
     GLDPRIGNKF LNAGIGYGGS CFHPDEVLFI DRGRGLECIT FKELFELEDK DNVKILSFDG
     EKLSLKKLKL ASKRYYNDDL ITLRFNLGRE IKITKDHPVV ILEDGELKIK LTSDVKEGDK
     VILPYGNFGE EREIEIDILE ELSKTDLIEK VWIHNKDLAT NEFNIIKPYL SNKYPHDVKR
     NGTIRAKDIL PIKEILDKYG SKNRLFTAKS KSTTIPYKIK IDKDFARLIG YYLSEGWISK
     DYGRNGVVRK RIGLCFGIHE EEYINDVKNI LNKLGIKYIE KIKDGSHSIL ISSKILAYVF
     ENILNCGINC YNKNIPPQMF NAKEEIKWEF LKGLFRGDGG IVRLNNNKNL NIEFATVSKK
     MAHSLLILLQ LLGIVASVKK CYNNKSTTMA YIIRINGLEQ VKKIGELFGK KWENYKDIAE
     SYKRNIEPLG YKKSDNFAIL EVKEIIKEHY SGYVYSVETE NSLLITSYGI LIHNCFPKDV
     KALIKQFENN NIEPILIKAT DIVNEEQIKW FFEKIKNYYG NLNGKTFAVL GLAFKPNTDD
     LRESRAIKLI DMLLESGAIV KGFDYVEKAR ENTINMYKLD KSKGFYGYNL YVLDDLYETV
     KNVDGIIITV EYDFNKEDWE KIGNLVKEKV VFDGRNILDV EKIKKLGFKY YGVGR