ID   Y1056_STRP1             Reviewed;         339 AA.
AC   Q99ZV5; Q48Z21;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=UPF0324 membrane protein SPy_1056/M5005_Spy0779;
GN   OrderedLocusNames=SPy_1056, M5005_Spy0779;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0324 family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK33943.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51397.1; -; Genomic_DNA.
DR   RefSeq; NP_269222.1; NC_002737.2.
DR   AlphaFoldDB; Q99ZV5; -.
DR   STRING; 1314.HKU360_00846; -.
DR   PaxDb; Q99ZV5; -.
DR   EnsemblBacteria; AAK33943; AAK33943; SPy_1056.
DR   KEGG; spy:SPy_1056; -.
DR   KEGG; spz:M5005_Spy0779; -.
DR   PATRIC; fig|160490.10.peg.911; -.
DR   HOGENOM; CLU_033541_2_1_9; -.
DR   OMA; FGLWCAI; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018383; UPF0324_pro.
DR   PANTHER; PTHR30106; PTHR30106; 1.
DR   Pfam; PF03601; Cons_hypoth698; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="UPF0324 membrane protein SPy_1056/M5005_Spy0779"
FT                   /id="PRO_0000157464"
FT   TRANSMEM        25..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   339 AA;  36239 MW;  A03E1866CF0DD99A CRC64;
     MSTHLRKLPG LLLCLLLALP AWCLGRLFPI IGAPVFAILL GMLLALFYEH RDKTKEGISF
     TSKYILQTAV VLLGFGLNLT QVMAVGMQSL PIIISTIATA LLVAYGLQKW LRLDVNTATL
     VGVGSSICGG SAVAATAPVI KAKDDEVAKA ISVIFLFNML AALLFPSLGQ LLGLSNEGFA
     IFAGTAVNDT SSVTATATAW DALHHSNTLD GATIVKLTRT LAILPITLGL SLYRAKKEHD
     IVTEENFSLR KSFPRFILFF LLASLITTLM TSLGVSADSF HYLKTLSKFF IVMAMAAIGL
     NTNLVKLIKT GGQAILLGAI CWVAITLVSL AMQLSLGIW