ID   Y1057_MYCTU             Reviewed;         393 AA.
AC   O53405; I6Y5H9; L0T8B2;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Seven-bladed beta-propeller protein Rv1057 {ECO:0000303|PubMed:16352831};
GN   OrderedLocusNames=Rv1057 {ECO:0000312|EMBL:CCP43808.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RX   PubMed=16352831; DOI=10.1128/jb.188.1.150-159.2006;
RA   Haydel S.E., Clark-Curtiss J.E.;
RT   "The Mycobacterium tuberculosis TrcR response regulator represses
RT   transcription of the intracellularly expressed Rv1057 gene, encoding a
RT   seven-bladed beta-propeller.";
RL   J. Bacteriol. 188:150-159(2006).
RN   [3] {ECO:0007744|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   INDUCTION.
RX   PubMed=22099420; DOI=10.1016/j.tube.2011.10.024;
RA   Pang X., Cao G., Neuenschwander P.F., Haydel S.E., Hou G., Howard S.T.;
RT   "The beta-propeller gene Rv1057 of Mycobacterium tuberculosis has a complex
RT   promoter directly regulated by both the MprAB and TrcRS two-component
RT   systems.";
RL   Tuberculosis 91:S142-S149(2011).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=H37Rv;
RX   PubMed=29134265; DOI=10.1007/s00284-017-1394-8;
RA   Fu J., Zong G., Zhang P., Gu Y., Cao G.;
RT   "Deletion of the beta-propeller protein gene Rv1057 reduces ESAT-6
RT   secretion and intracellular growth of Mycobacterium tuberculosis.";
RL   Curr. Microbiol. 75:401-409(2018).
CC   -!- FUNCTION: May play an important role in host-pathogen interactions and
CC       in ESAT-6 secretion. {ECO:0000269|PubMed:29134265}.
CC   -!- INDUCTION: Expression increases during early growth in macrophages
CC       (PubMed:16352831). Expression is directly regulated by both the MprAB
CC       and TrcRS two-component systems (PubMed:16352831, PubMed:22099420).
CC       Negatively regulated by TrcS/TrcR (PubMed:16352831). Activated by
CC       MprA/MprB under envelope stress (PubMed:22099420). Expression may also
CC       be regulated by sigma E (PubMed:16352831).
CC       {ECO:0000269|PubMed:16352831, ECO:0000269|PubMed:22099420}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene does not affect the
CC       synthesis of the major virulence factor ESAT-6, but greatly reduces its
CC       secretion. In infected macrophages, Rv1057 deletion significantly
CC       reduces the secretion levels of cytokines IL-1 beta, IL-10, TNF-alpha,
CC       and INF-gamma, but does not affect IL-4 and IL-8 levels. Deletion of
CC       Rv1057 greatly impairs the ability of M.tuberculosis to replicate in
CC       macrophages. {ECO:0000269|PubMed:29134265}.
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DR   EMBL; AL123456; CCP43808.1; -; Genomic_DNA.
DR   RefSeq; NP_215573.1; NC_000962.3.
DR   RefSeq; WP_003405622.1; NZ_NVQJ01000060.1.
DR   AlphaFoldDB; O53405; -.
DR   SMR; O53405; -.
DR   STRING; 83332.Rv1057; -.
DR   PaxDb; O53405; -.
DR   PRIDE; O53405; -.
DR   GeneID; 887135; -.
DR   KEGG; mtu:Rv1057; -.
DR   PATRIC; fig|83332.111.peg.1176; -.
DR   TubercuList; Rv1057; -.
DR   eggNOG; COG3391; Bacteria.
DR   OMA; YVASCGP; -.
DR   PhylomeDB; O53405; -.
DR   Proteomes; UP000001584; Chromosome.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011048; Haem_d1_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   SUPFAM; SSF51004; SSF51004; 2.
PE   1: Evidence at protein level;
KW   Reference proteome; Stress response; Virulence.
FT   CHAIN           1..393
FT                   /note="Seven-bladed beta-propeller protein Rv1057"
FT                   /id="PRO_0000451064"
FT   REGION          208..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   393 AA;  40711 MW;  3116656C31971CD0 CRC64;
     MSVMNGREVA RESRDAQVFE FGTAPGSAVV KIPVQGGPIG GIAISRDGSL LVVTNNGTDT
     VSVVGTDTCR VTQTVTSVNE PFAIAMGNAE ANRAYVSTVS SAYDAIAVID VATNTVLGTH
     PLALSVSDLT LSPDDKYLYV SRNGTRGADV AVLDTTTGAL IDVVDVSQAP GTTTQCVRMS
     PDGSVLYVGA NGPSGGLLVV ITTRAQSDGG RIGSRSRSRQ KSSKPRGNQA AAGLRVVATI
     DIGSSVRDVA LSPDGAIAYV ASCGSDFGAV VDVIDTRTHQ ITSSRAISEI GGLVTRVSVS
     GDADRAYLVS EDRVTVLCTR THDVIGTIRT GQPSCVVESP DGKYLYIADY SGTITRTAVA
     STIVSGTEQL ALQRRGSMQW FSPELQQYAP ALA