ID   Y1063_MYCTO             Reviewed;         360 AA.
AC   P9WIY8; L0T771; O53411; P67098;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized NTE family protein MT1093;
GN   OrderedLocusNames=MT1093;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45347.1; -; Genomic_DNA.
DR   PIR; E70892; E70892.
DR   RefSeq; WP_003405642.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIY8; -.
DR   SMR; P9WIY8; -.
DR   EnsemblBacteria; AAK45347; AAK45347; MT1093.
DR   KEGG; mtc:MT1093; -.
DR   PATRIC; fig|83331.31.peg.1176; -.
DR   HOGENOM; CLU_047251_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism.
FT   CHAIN           1..360
FT                   /note="Uncharacterized NTE family protein MT1093"
FT                   /id="PRO_0000427922"
FT   DOMAIN          19..179
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          251..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           50..54
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           166..168
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        52
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        166
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ   SEQUENCE   360 AA;  37523 MW;  F08C30CE6096D0F6 CRC64;
     MPAPAALRVR GSSSPRVALA LGSGGARGYA HIGVIQALRE RGYDIVGIAG SSMGAVVGGV
     HAAGRLDEFA HWAKSLTQRT ILRLLDPSIS AAGILRAEKI LDAVRDIVGP VAIEQLPIPY
     TAVATDLLAG KSVWFQRGPL DAAIRASIAI PGVIAPHEVD GRLLADGGIL DPLPMAPIAG
     VNADLTIAVS LNGSEAGPAR DAEPNVTAEW LNRMVRSTSA LFDVSAARSL LDRPTARAVL
     SRFGAAAAES DSWSQAPEIE QRPAGPPADR EEAADTPGLP KMGSFEVMNR TIDIAQSALA
     RHTLAGYPAD LLIEVPRSTC RSLEFHRAVE VIAVGRALAT QALEAFEIDD DESAAATIEG